Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A1 | O15245 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.63 |
| ▸ | DNM1 | Q05193 | 6/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9125508 | 1.00 | SLC22A1 (0.68) | SLC22A1ALDH1A1TP53CYP3A4ALOX15 | |
| Hydrochloric Acid SCHEMBL15538720 | 1.00 | SLC22A1 (0.68) | SLC22A1ALDH1A1TP53CYP3A4ALOX15 | |
| Hydrochloric Acid SCHEMBL30472877 | 1.00 | SLC22A1 (0.68) | SLC22A1ALDH1A1TP53CYP3A4ALOX15 | |
| Hydrochloric Acid SCHEMBL5389333 | 1.00 | SLC22A1 (0.68) | SLC22A1ALDH1A1TP53CYP3A4ALOX15 | |
| Hydrochloric Acid SCHEMBL2772680 | 1.00 | SLC22A1 (0.68) | SLC22A1ALDH1A1TP53CYP3A4ALOX15 | |
| Hydrochloric Acid SCHEMBL5352695 | 1.00 | SLC22A1 (0.68) | SLC22A1ALDH1A1TP53CYP3A4ALOX15 | |
| Hydrochloric Acid SCHEMBL4892697 | 1.00 | SLC22A1 (0.68) | SLC22A1ALDH1A1TP53CYP3A4ALOX15 | |
| Hydrochloric Acid SCHEMBL14777978 | 1.00 | SLC22A1 (0.68) | SLC22A1ALDH1A1TP53CYP3A4ALOX15 | |
| Hydrochloric Acid SCHEMBL5350154 | 1.00 | SLC22A1 (0.68) | SLC22A1ALDH1A1TP53CYP3A4ALOX15 | |
| Hydrochloric Acid SCHEMBL30472878 | 0.97 | SLC22A1 (0.65) | SLC22A1ALDH1A1TP53CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120107389-A1 | AMPHOTERIC LIPOSOMAL COMPOSITIONS FOR CELLULAR DELIVERY OF SMALL RNA MOLECULES FOR USE IN RNA INTERFERENCE | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2012-05-03 | — | — | US | claimed |
| US-9763881-B2 | Rice bran-lipids based formulation and process for preparation thereof for selective delivery of genes to cancer cells | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2017-09-19 | — | — | US | disclosed |
| US-20150164797-A1 | RICE BRAN-LIPIDS BASED FORMULATION AND PROCESS FOR PREPARATION THEREOF FOR SELECTIVE DELIVERY OF GENES TO CANCER CELLS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2015-06-18 | — | — | US | disclosed |
| US-8329681-B2 | Methods and compositions for the efficient delivery of therapeutic agents to cells and animals | UNIVERSITY OF MASSACHUSETTS (US) | 2012-12-11 | — | — | US | disclosed |
| US-20120107389-A1 | AMPHOTERIC LIPOSOMAL COMPOSITIONS FOR CELLULAR DELIVERY OF SMALL RNA MOLECULES FOR USE IN RNA INTERFERENCE | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2012-05-03 | — | — | US | disclosed |
| EP-2414519-A1 | AMPHOTERIC LIPOSOMAL COMPOSITIONS FOR CELLULAR DELIVERY OF SMALL RNA MOLECULES FOR USE IN RNA INTERFERENCE | Council of Scientific & Industrial Research (IN) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010113172-A1 | AMPHOTERIC LIPOSOMAL COMPOSITIONS FOR CELLULAR DELIVERY OF SMALL RNA MOLECULES FOR USE IN RNA INTERFERENCE | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2010-10-07 | — | — | WO | disclosed |
| EP-1940775-A2 | METHODS AND COMPOSITIONS FOR THE EFFICIENT DELIVERY OF THERAPEUTIC AGENTS TO CELLS AND ANIMALS | University of Massachusetts (US) | 2008-07-09 | — | — | EP | disclosed |
| US-20070260055-A1 | Methods and compositions for the efficient delivery of therapeutic agents to cells and animals | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-11-08 | — | — | US | disclosed |
| WO-2007022030-A2 | METHODS AND COMPOSITIONS FOR THE EFFICIENT DELIVERY OF THERAPEUTIC AGENTS TO CELLS AND ANIMALS | UNIVERSITY OF MASSACHUSETTS (US) | 2007-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070260055-A1 | Methods and compositions for the efficient delivery of therapeutic agents to cells and animals | ABCB4, PIGS, CETP | SLC22A1 767/4885ALDH1A1 1072/4885TP53 1011/4885 |
| US-20120107389-A1 | AMPHOTERIC LIPOSOMAL COMPOSITIONS FOR CELLULAR DELIVERY OF SMALL RNA MOLECULES FOR USE IN RNA INTERFERENCE | ANXA6, DDHD2, ABHD16A | SLC22A1 697/4885ALDH1A1 4705/4885TP53 2812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.