Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2264767 | 0.77 | ERN1 (0.44) | ERN1ALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL1748919 | 0.77 | MEN1 (0.48) | ALDH1A1CYP1A2CYP2C19KDM4EMAPT | |
| SCHEMBL633855 | 0.75 | AHR (0.42) | ERN1CYP2A6BACE1 | |
| SCHEMBL5372057 | 0.75 | MEN1 (0.47) | ALDH1A1CYP1A2MEN1POLBMAPK1 | |
| SCHEMBL985652 | 0.75 | MEN1 (0.47) | ALDH1A1CYP1A2KDM4EMAPTMEN1 | |
| SCHEMBL24165715 | 0.75 | MEN1 (0.43) | CYP1A2MEN1POLBMAPK1KMT2A | |
| SCHEMBL12422248 | 0.74 | MEN1 (0.46) | ALDH1A1CYP1A2MEN1POLBMAPK1 | |
| SCHEMBL4886068 | 0.74 | ERN1 (0.44) | ERN1CYP2A6BACE1TDP1 | |
| SCHEMBL30310568 | 0.74 | MEN1 (0.46) | ALDH1A1CYP1A2MEN1POLBMAPK1 | |
| SCHEMBL24762249 | 0.74 | MEN1 (0.46) | ALDH1A1CYP1A2KDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| US-20070213362-A1 | 2-NH-HETEROARYLIMIDAZOLES WITH ANTIBACTERIAL ACTIVITY | REPLIDYNE, INC. (US) | 2007-09-13 | — | — | US | disclosed |
| US-7220757-B2 | Compositions and methods for topical administration of 2-NH-heteroarylimidazoles | REPLIDYNE, INC. (US) | 2007-05-22 | — | — | US | disclosed |
| EP-1619947-A4 | ANTIBACTERIAL METHODS AND COMPOSITIONS | REPLIDYNE INC (US) | 2006-05-31 | — | — | EP | disclosed |
| EP-1619947-A2 | ANTIBACTERIAL METHODS AND COMPOSITIONS | Replidyne, Inc. (US) | 2006-02-01 | — | — | EP | disclosed |
| US-20060014748-A1 | 2-NH-heteroarylimidazoles with antibacterial activity | BERGE JOHN | 2006-01-19 | — | — | US | disclosed |
| EP-1581220-A2 | 2-NH-HETEROARYLIMIDAZOLES WITH ANTIBACTERIAL ACTIVITY | Replidyne, Inc. (US) | 2005-10-05 | — | — | EP | disclosed |
| US-6943175-B2 | 2-NH-heteroarylimidazoles with antibacterial activity | REPLIDYNE, INC. (US) | 2005-09-13 | — | — | US | disclosed |
| WO-2005009336-A9 | ANTIBACTERIAL METHODS AND COMPOSITIONS | REPLIDYNE INC (US) | 2005-04-14 | — | — | WO | disclosed |
| WO-2005009336-A2 | ANTIBACTERIAL METHODS AND COMPOSITIONS | REPLIDYNE, INC. (US) | 2005-02-03 | — | — | WO | disclosed |
| US-20040224981-A1 | Antibacterial methods and compositions | REPLIDYNE, INC. | 2004-11-11 | — | — | US | disclosed |
| US-20040147548-A1 | 2-NH-heteroarylimidazoles with antibacterial activity | REPLIDYNE, INC. | 2004-07-29 | — | — | US | disclosed |
| WO-2004052288-A2 | 2-NH-HETEROARYLIMIDAZOLES WITH ANTIBACTERIAL ACTIVITY | REPLIDYNE, INC. (US) | 2004-06-24 | — | — | WO | disclosed |
| WO-2000071524-A1 | 2-NH-PYRIDONES AND PYRIMIDONES AS MRS INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147548-A1 | 2-NH-heteroarylimidazoles with antibacterial activity | NSUN3, TRMT1, NOP2 | ERN1 548/4885ALDH1A1 1318/4885CYP1A2 1050/4885 |
| US-20040224981-A1 | Antibacterial methods and compositions | AARS1, NOP2, NSUN3 | ERN1 334/4885ALDH1A1 3226/4885CYP1A2 4292/4885 |
| US-20070213362-A1 | 2-NH-HETEROARYLIMIDAZOLES WITH ANTIBACTERIAL ACTIVITY | MET, ASNS, MRPS22 | ERN1 2143/4885ALDH1A1 2083/4885CYP1A2 943/4885 |
| US-20060014748-A1 | 2-NH-heteroarylimidazoles with antibacterial activity | TRMT1, NSUN3, NOP2 | ERN1 712/4885ALDH1A1 1422/4885CYP1A2 956/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.