Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 17/20 | 0.49 |
| ▸ | THRA | P10827 | 16/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5388207 | 0.92 | THRB (0.49) | THRBTHRAALDH1A1GAAGFER | |
| SCHEMBL5386441 | 0.89 | THRB (0.56) | THRBTHRAALDH1A1GAAGFER | |
| SCHEMBL3923780 | 0.86 | THRA (0.55) | THRBTHRAALDH1A1GAAGFER | |
| SCHEMBL5393458 | 0.86 | THRB (0.49) | THRBTHRAALDH1A1GAAGFER | |
| SCHEMBL5396340 | 0.85 | THRA (0.43) | THRBTHRAALDH1A1GAAGFER | |
| SCHEMBL2434505 | 0.83 | ALDH1A1 (0.64) | ALDH1A1GAAGFERHSP90AB1LMNA | |
| Hydrochloric Acid SCHEMBL6560031 | 0.82 | ALDH1A1 (0.62) | ALDH1A1GAAGFERHSP90AB1LMNA | |
| SCHEMBL5742868 | 0.81 | THRB (0.57) | THRBTHRAHSP90AB1LMNA | |
| SCHEMBL3914044 | 0.80 | THRA (0.50) | THRBTHRAALDH1A1GAALMNA | |
| SCHEMBL5385620 | 0.78 | THRB (0.67) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7199265-B2 | Thyroid receptor ligands, pharmaceutical compositions comprising them and their use in the treatment of disorders influenced by thyroid hormones | KARO BIO AB (SE) | 2007-04-03 | — | — | US | disclosed |