Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.42 |
| ▸ | RARA | P10276 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 1/20 | 0.41 |
| ▸ | RARG | P13631 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | RGS12 | O14924 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL1662353 | 0.80 | RARA (0.47) | BACE1ALOX5RARARARBRARG | |
| Ethylamine SCHEMBL11810037 | 0.80 | ALOX5 (0.50) | BACE1ALOX5RARARARBRARG | |
| Methylamine SCHEMBL28044974 | 0.77 | — | — | |
| Pyruvate SCHEMBL935493 | 0.77 | RARA (0.45) | BACE1ALOX5RARARARBRARG | |
| Glycine SCHEMBL252376 | 0.77 | GLRA1 (0.62) | GLRA1SLC6A9OR51E2LMNAGAA | |
| Glycine SCHEMBL4201161 | 0.75 | GLRA1 (0.42) | BACE1GLRA1SLC6A9OR51E2KDM4E | |
| Methane SCHEMBL28580924 | 0.74 | APP (0.41) | BACE1ALOX5RARARARBRARG | |
| Formic Acid SCHEMBL27598190 | 0.73 | APP (0.44) | BACE1ALOX5RARARARBRARG | |
| SCHEMBL29171599 | 0.72 | APP (0.48) | BACE1ALOX5RARARARBRARG | |
| Boric Acid SCHEMBL29171600 | 0.72 | APP (0.48) | BACE1ALOX5RARARARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7183319-B2 | Phenylethylamine derivatives and their use in the treatment of melanoma | RILEY PATRICK ANTHONY | 2007-02-27 | — | — | US | disclosed |
| EP-1427694-A4 | FLUORINE-CONTAINING COMPOUNDS AND POLYMERS DERIVED THEREFROM | HONEYWELL INT INC (US) | 2005-06-22 | — | — | EP | disclosed |
| EP-1451235-A4 | FLUORINE-CONTAINING COMPOUNDS AND POLYMERS DERIVED THEREFROM | HONEYWELL INT INC (US) | 2005-06-22 | — | — | EP | disclosed |
| US-6809216-B2 | WATERPROOFING, OIL REPELLENTS, ANTISOILANTS | HONEYWELL INTERNATIONAL INC. | 2004-10-26 | — | — | US | disclosed |
| US-6800788-B2 | FLUORINE-CONTAINING COMPOUNDS, AND POLYMERS DERIVED THEREFROM, FOR USE IN COMPOSITIONS USED FOR TREATING TEXTILE SUBSTRATES. ALSO PROVIDED ARE METHODS OF MAKING FLUORINE-CONTAINING COMPOUNDS AND POLYMERS DERIVED THEREFROM, COMPOSITIONS | HONEYWELL INTERNATIONAL INC. | 2004-10-05 | — | — | US | disclosed |
| EP-1451235-A2 | FLUORINE-CONTAINING COMPOUNDS AND POLYMERS DERIVED THEREFROM | Honeywell International Inc. (US) | 2004-09-01 | — | — | EP | disclosed |
| EP-1427694-A1 | FLUORINE-CONTAINING COMPOUNDS AND POLYMERS DERIVED THEREFROM | Honeywell International Inc. (US) | 2004-06-16 | — | — | EP | disclosed |
| US-20040029967-A1 | Phenylethylamine derivatives and their use in the treatment of melanoma | RILEY PATRICK ANTHONY (GB) | 2004-02-12 | — | — | US | disclosed |
| US-20030109626-A1 | Fluorine-containing compounds and polymers derived therefrom | HONEYWELL INTERNATIONAL INC. | 2003-06-12 | — | — | US | disclosed |
| US-20030092828-A1 | Fluorine-containing compounds and polymers derived therefrom | BRADLEY DAVID E (US) | 2003-05-15 | — | — | US | disclosed |
| WO-2002103103-A2 | FLUORINE-CONTAINING COMPOUNDS AND POLYMERS DERIVED THEREFROM | HONEYWELL INTERNATIONAL INC. (US) | 2002-12-27 | — | — | WO | disclosed |
| WO-2002102758-A1 | FLUORINE-CONTAINING COMPOUNDS AND POLYMERS DERIVED THEREFROM | HONEYWELL INTERNATIONAL, INC. (US) | 2002-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030109626-A1 | Fluorine-containing compounds and polymers derived therefrom | WASF2, NOTUM, NEFM | BACE1 1224/4885ALOX5 451/4885GLRA1 4244/4885 |
| US-20040029967-A1 | Phenylethylamine derivatives and their use in the treatment of melanoma | DOHH, DBH, HRH4 | BACE1 3633/4885ALOX5 2907/4885GLRA1 897/4885 |
| US-20030092828-A1 | Fluorine-containing compounds and polymers derived therefrom | WASF2, NOTUM, PFAS | BACE1 1172/4885ALOX5 527/4885GLRA1 4342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.