Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 12/20 | 0.37 |
| ▸ | BRAF | P15056 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL539284 | 0.80 | MEN1 (0.47) | AKT1RAB9AMEN1NPC1NR2F2 | |
| SCHEMBL538968 | 0.79 | AKT1 (0.41) | AKT1 | |
| SCHEMBL868394 | 0.77 | AKT1 (0.62) | AKT1 | |
| SCHEMBL538092 | 0.77 | ADORA1 (0.39) | AKT1RAB9AHTTMEN1NPC1 | |
| SCHEMBL538967 | 0.75 | AKT1 (0.43) | AKT1 | |
| SCHEMBL538716 | 0.73 | AKT1 (0.41) | AKT1GAAMEN1KMT2AALDH1A1 | |
| SCHEMBL538545 | 0.71 | AKT1 (0.38) | AKT1 | |
| SCHEMBL538707 | 0.71 | MAP4K4 (0.42) | AKT1GAAHTTMEN1KMT2A | |
| SCHEMBL538827 | 0.71 | ALOX5 (0.45) | GAARAB9AHTTMEN1NPC1 | |
| SCHEMBL538122 | 0.71 | ALOX5 (0.43) | AKT1ALDH1A1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413932-A1 | INHIBITORS OF AKT ACTIVITY | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | claimed |
| WO-2010114780-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | claimed |