Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 10/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 4/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.37 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL538092 | 0.81 | ADORA1 (0.39) | MEN1NPC1NR2F2RAB9AKMT2A | |
| SCHEMBL538833 | 0.80 | AKT1 (0.37) | MEN1NPC1NR2F2RAB9AKMT2A | |
| SCHEMBL538716 | 0.76 | AKT1 (0.41) | MEN1KMT2AMAPTALDH1A1AKT1 | |
| SCHEMBL538266 | 0.76 | AKT1 (0.40) | MEN1NPC1RAB9AKMT2AMAPT | |
| SCHEMBL538519 | 0.76 | AKT1 (0.48) | MEN1NPC1NR2F2RAB9AKMT2A | |
| SCHEMBL867572 | 0.74 | AKT1 (0.63) | AKT1 | |
| SCHEMBL538545 | 0.74 | AKT1 (0.38) | MAPTADORA1AKT1AKT2 | |
| SCHEMBL538827 | 0.74 | ALOX5 (0.45) | MEN1NPC1RAB9AKMT2AMAPT | |
| SCHEMBL538707 | 0.74 | MAP4K4 (0.42) | MEN1KMT2AMAPTALDH1A1PIM1 | |
| SCHEMBL538122 | 0.74 | ALOX5 (0.43) | MAPTALDH1A1ADORA1AKT1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413932-A1 | INHIBITORS OF AKT ACTIVITY | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114780-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |