Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 7/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 6/20 | 0.41 |
| ▸ | CSNK1E | P49674 | 6/20 | 0.41 |
| ▸ | AKT2 | P31751 | 2/20 | 0.39 |
| ▸ | CALCA | P06881 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL538092 | 0.95 | ADORA1 (0.39) | AKT1AKT2MEN1KMT2AKDM4E | |
| SCHEMBL538707 | 0.93 | MAP4K4 (0.42) | AKT1CSNK1DCSNK1EAKT2MEN1 | |
| SCHEMBL538827 | 0.87 | ALOX5 (0.45) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL538545 | 0.77 | AKT1 (0.38) | AKT1AKT2MAPT | |
| SCHEMBL868195 | 0.76 | AKT1 (0.67) | AKT1AKT2 | |
| SCHEMBL539284 | 0.76 | MEN1 (0.47) | AKT1AKT2MEN1KMT2AALDH1A1 | |
| SCHEMBL538266 | 0.75 | AKT1 (0.40) | AKT1AKT2MEN1KMT2AKDM4E | |
| SCHEMBL538833 | 0.73 | AKT1 (0.37) | AKT1MEN1KMT2AALDH1A1GAA | |
| SCHEMBL10167543 | 0.71 | AKT1 (0.51) | AKT1AKT2 | |
| SCHEMBL538391 | 0.71 | AKT1 (0.51) | AKT1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413932-A1 | INHIBITORS OF AKT ACTIVITY | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | claimed |
| WO-2010114780-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | claimed |
| EP-2413932-A1 | INHIBITORS OF AKT ACTIVITY | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114780-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |