Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | STAT1 | P42224 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ACACA | Q13085 | 1/20 | 0.40 |
| ▸ | MERTK | Q12866 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL538092 | 0.92 | ADORA1 (0.39) | ALOX5MAPTNPC1RAB9AKDM4E | |
| SCHEMBL538716 | 0.87 | AKT1 (0.41) | ALOX5MAPTLMNAALDH1A1L3MBTL1 | |
| SCHEMBL538707 | 0.85 | MAP4K4 (0.42) | MAPTLMNAALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL868528 | 0.78 | AKT1 (0.62) | — | |
| SCHEMBL538122 | 0.75 | ALOX5 (0.43) | ALOX5MAPTALDH1A1SMN1; SMN2ATM | |
| SCHEMBL539284 | 0.74 | MEN1 (0.47) | MAPTALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL538266 | 0.73 | AKT1 (0.40) | MAPTALDH1A1L3MBTL1NPC1RAB9A | |
| SCHEMBL538545 | 0.71 | AKT1 (0.38) | MAPT | |
| SCHEMBL538833 | 0.71 | AKT1 (0.37) | ALOX5ALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL538528 | 0.69 | ADORA3 (0.40) | ALOX5MAPTNPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413932-A1 | INHIBITORS OF AKT ACTIVITY | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | claimed |
| WO-2010114780-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | claimed |