Brasofensine

Brasofensine

SCHEMBL539079

CO/N=C/[C@@H]1[C@@H](c2ccc(Cl)c(Cl)c2)C[C@@H]2CC[C@H]1N2C

nearest known ligand 0.60

Full drug profile on Sugi Atlas →

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
SLC6A3 Q01959 11/20 0.60
SLC6A4 P31645 7/20 0.60
SLC6A2 P23975 3/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Brasofensine SCHEMBL1649206 1.00 SLC6A3 (0.60) SLC6A3SLC6A4SLC6A2
Brasofensine SCHEMBL20390946 1.00 SLC6A3 (0.60) SLC6A3SLC6A4SLC6A2
Brasofensine SCHEMBL14762214 1.00 SLC6A3 (0.60) SLC6A3SLC6A4SLC6A2
Brasofensine SCHEMBL20390950 1.00 SLC6A3 (0.60) SLC6A3SLC6A4SLC6A2
Brasofensine SCHEMBL5031138 0.94 SLC6A3 (0.58) SLC6A3SLC6A4SLC6A2
Brasofensine SCHEMBL29426326 0.92 SLC6A3 (0.58) SLC6A3SLC6A4SLC6A2
SCHEMBL3671497 0.89 SLC6A3 (0.59) SLC6A3SLC6A4SLC6A2
Hydrochloric Acid SCHEMBL7362088 0.88 SLC6A3 (0.58) SLC6A3SLC6A4SLC6A2
SCHEMBL7460089 0.86 SLC6A3 (0.59) SLC6A3SLC6A4SLC6A2
SCHEMBL7455410 0.86 SLC6A3 (0.59) SLC6A3SLC6A4SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025111482-A1 COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS BEXSON BIOMEDICAL, INC. (US) 2025-05-30 WO claimed
US-20250032503-A1 USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE HOTH THERAPEUTICS, INC. 2025-01-30 US claimed
EP-4360628-A2 COMPOSITIONS AND METHODS FOR INCREASING THE METABOLIC LIFETIME OF DEXTROMETHORPHAN AND RELATED PHARMACODYNAMIC EFFECTS Antecip Bioventures II LLC (US) 2024-05-01 EP claimed
EP-4297868-A1 USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE Hoth Therapeutics, Inc. (US) 2024-01-03 EP claimed
US-20230285387-A1 COMBINATION OF MORPHINAN COMPOUNDS AND ANTIDEPRESSANT FOR THE TREATMENT OF PSEUDOBULBAR AFFECT, NEUROLOGICAL DISEASES, INTRACTABLE AND CHRONIC PAIN AND BRAIN INJURY CONCERT PHARMACEUTICALS, INC. 2023-09-14 US claimed
EP-4106872-A1 COMPOSITIONS AND METHODS FOR ASSESSING THE EFFICACY OF INHIBITORS OF NEUROTRANSMITTER TRANSPORTERS Denovo Biopharma LLC (US) 2022-12-28 EP claimed
US-11478467-B2 Targeted drug rescue with novel compositions, combinations, and methods thereof Exciva GmbH (DE) 2022-10-25 US claimed
US-20220296586-A1 NOVEL COMPOSITIONS, COMBINATIONS, AND METHODS THEREOF Vepachedu, Sreenivasarao (US) 2022-09-22 US claimed
WO-2022182658-A1 USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE HOTH THERAPEUTICS, INC. (US) 2022-09-01 WO claimed
EP-1931320-B1 MICROPARTICLES WITH MODIFIED RELEASE OF AT LEAST ONE ACTIVE PRINCIPLE AND ORAL DOSAGE FORM COMPRISING THE SAME FLAMEL IRELAND LTD (IE) 2022-06-15 EP claimed
CN-101277684-A Microparticles for the modified release of at least one active principle and oral pharmaceutical forms containing them FLAMEL TECH SA (FR) 2008-10-01 CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
EP-1931320-A2 MICROPARTICLES WITH MODIFIED RELEASE OF AT LEAST ONE ACTIVE PRINCIPLE AND ORAL GALENIC FORM COMPRISING SAME Flamel Technologies (FR) 2008-06-18 EP claimed
WO-2007148341-A2 NOVEL SEROTONIN REUPTAKE INHIBITORS AS DRUGS HAVING PERIPHERAL-SYSTEM-RESTRICTED ACTIVITY RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) 2007-12-27 WO claimed
US-20070225379-A1 Analgesic, Parkinson or Alzheimer drug in a solvent system containing a monoalkyl ether of diethylene glycol, a glycol, and a mixture of a C2 to C4 alcohol and water; inhibits crystallization and transfer to clothing, improves and modulates bioavailability within skin layers; nonocclusive, semi-solid ANTARES PHARMA, INC. 2007-09-27 US claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
WO-2007036671-A2 MICROPARTICLES WITH MODIFIED RELEASE OF AT LEAST ONE ACTIVE PRINCIPLE AND ORAL GALENIC FORM COMPRISING SAME FLAMEL TECHNOLOGIES (FR) 2007-04-05 WO claimed
US-6929801-B2 Transdermal delivery of antiparkinson agents ACRUX DDS PTY LTD (AU) 2005-08-16 US claimed
US-20040013620-A1 Transdermal delivery of antiparkinson agents MONASH UNIVERSITY 2004-01-22 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11478467-B2 Targeted drug rescue with novel compositions, combinations, and methods thereof HTR2A, HTR2C, CYP3A43 SLC6A3 218/4885SLC6A4 68/4885SLC6A2 42/4885
US-20230285387-A1 COMBINATION OF MORPHINAN COMPOUNDS AND ANTIDEPRESSANT FOR THE TREATMENT OF PSEUDOBULBAR AFFECT, NEUROLOGICAL DISEASES, INTRACTABLE AND CHRONIC PAIN AND BRAIN INJURY MAOB, DBH, OPRL1 SLC6A3 9/4885SLC6A4 14/4885SLC6A2 4/4885
US-20250032503-A1 USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE TACR1, ACHE, TACR2 SLC6A3 1329/4885SLC6A4 1763/4885SLC6A2 1338/4885
US-20220296586-A1 NOVEL COMPOSITIONS, COMBINATIONS, AND METHODS THEREOF CYP2D6, HTR2A, CYP3A43 SLC6A3 229/4885SLC6A4 110/4885SLC6A2 68/4885
US-20040013620-A1 Transdermal delivery of antiparkinson agents SLC6A3, TYR, SLC18A3 SLC6A3 1/4885SLC6A4 15/4885SLC6A2 4/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.