Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Brasofensine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 known ✓ | Q01959 | 11/20 | 0.58 |
| ▸ | SLC6A4 known ✓ | P31645 | 8/20 | 0.58 |
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Brasofensine SCHEMBL539079 | 0.92 | SLC6A3 (0.60) | SLC6A3SLC6A4SLC6A2 | |
| Brasofensine SCHEMBL14762214 | 0.92 | SLC6A3 (0.60) | SLC6A3SLC6A4SLC6A2 | |
| Brasofensine SCHEMBL20390950 | 0.92 | SLC6A3 (0.60) | SLC6A3SLC6A4SLC6A2 | |
| Brasofensine SCHEMBL1649206 | 0.92 | SLC6A3 (0.60) | SLC6A3SLC6A4SLC6A2 | |
| Brasofensine SCHEMBL20390946 | 0.92 | SLC6A3 (0.60) | SLC6A3SLC6A4SLC6A2 | |
| Brasofensine SCHEMBL5031138 | 0.90 | SLC6A3 (0.58) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL7455410 | 0.87 | SLC6A3 (0.59) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL7460089 | 0.87 | SLC6A3 (0.59) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL3671497 | 0.82 | SLC6A3 (0.59) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL7358592 | 0.81 | SLC6A3 (0.57) | SLC6A3SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3157408-B1 | DEVICES TO PROVIDE HANDS FREE SCLERAL DEPRESSION DURING OPHTHALMIC PROCEDURES | ALCON INC (CH) | 2026-03-25 | — | — | EP | disclosed |
| EP-4714407-A2 | DEVICES TO PROVIDE HANDS FREE SCLERAL DEPRESSION DURING OPHTHALMIC PROCEDURES | Alcon Inc. (CH) | 2026-03-25 | — | — | EP | disclosed |
| EP-4687890-A1 | METHODS FOR TREATING DEPRESSIVE STATES | BioXcel Therapeutics, Inc. (US) | 2026-02-11 | — | — | EP | disclosed |
| US-20250057694-A1 | DEVICES AND METHODS TO PROVIDE HANDS FREE SCLERAL DEPRESSION AND ILLUMINATION DURING OPHTHALMIC PROCEDURES | Ganihand, LLC (US) | 2025-02-20 | — | — | US | disclosed |
| WO-2024211911-A1 | METHODS FOR TREATING DEPRESSIVE STATES | OAKTREE FUND ADMINISTRATION, LLC (US) | 2024-10-10 | — | — | WO | disclosed |
| US-11266395-B2 | Devices and methods to provide hands free scleral depression during ophthalmic procedures | Ganihand, LLC (US) | 2022-03-08 | — | — | US | disclosed |