Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.65 |
| ▸ | FBP1 | P09467 | 2/20 | 0.62 |
| ▸ | VCP | P55072 | 1/20 | 0.62 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | METAP1 | P53582 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9422259 | 0.85 | NFE2L2 (0.77) | NFE2L2FBP1VCPCYP19A1TSHR | |
| SCHEMBL18640461 | 0.85 | NFE2L2 (0.77) | NFE2L2FBP1VCPCYP19A1TSHR | |
| SCHEMBL29420866 | 0.85 | NFE2L2 (0.77) | NFE2L2FBP1VCPCYP19A1TSHR | |
| SCHEMBL28019580 | 0.84 | NFE2L2 (0.65) | NFE2L2FBP1VCPCYP19A1TSHR | |
| SCHEMBL15498134 | 0.83 | NFE2L2 (0.89) | NFE2L2FBP1VCPCYP19A1TSHR | |
| SCHEMBL14880346 | 0.83 | NFE2L2 (0.69) | NFE2L2FBP1VCPCYP19A1TSHR | |
| 3-Nitrobenzaldehyde SCHEMBL29573715 | 0.82 | NFE2L2 (0.67) | NFE2L2FBP1VCPCYP19A1TSHR | |
| 3-Nitrobenzaldehyde SCHEMBL54487 | 0.82 | NFE2L2 (0.67) | NFE2L2FBP1VCPCYP19A1TSHR | |
| SCHEMBL123416 | 0.80 | NFE2L2 (0.65) | NFE2L2FBP1VCPCYP19A1TSHR | |
| SCHEMBL9727291 | 0.80 | NFE2L2 (0.65) | NFE2L2FBP1VCPCYP19A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114181207-B | Beta-carboline compounds, preparation method thereof and application thereof in resisting Alzheimer disease | 中国人民解放军北部战区总医院 | 2022-12-13 | — | — | CN | claimed |
| CN-105541801-A | Method for synthesizing EZH2 methyltransferase inhibitor GSK126 | UNIV CHANGZHOU | 2016-05-04 | — | — | CN | claimed |
| CN-110325523-A | Carboxylic acid aromatic amides as bradykinin B1 receptor antagonists | 拜耳制药股份公司 | 2019-10-11 | — | — | CN | disclosed |
| WO-2019154366-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 江苏奥赛康药业有限公司 | 2019-08-15 | — | — | WO | disclosed |
| CN-105294670-B | Organic electroluminescent compounds and its organic photoelectric device | 上海天马有机发光显示技术有限公司 | 2019-07-09 | — | — | CN | disclosed |
| CN-106795154-B | Isoquinolinone derivatives for treating cancer | 皮埃尔法布雷医药公司 | 2019-07-05 | — | — | CN | disclosed |
| CN-109562111-A | CK2 inhibitor, its composition and method | 北极星药业股份有限公司 | 2019-04-02 | — | — | CN | disclosed |
| CN-105324379-B | Benzimidazole derivatives as bromodomain inhibitors | 吉利德科学公司 | 2018-12-04 | — | — | CN | disclosed |
| CN-108929263-A | Aryl amide Kv2.1 inhibitor and preparation method thereof, pharmaceutical composition and purposes | 中国医学科学院药物研究所 | 2018-12-04 | — | — | CN | disclosed |
| CN-107922375-A | Target the antitumoral compounds and its application method of IDH2 mutation | 正大天晴药业集团股份有限公司 | 2018-04-17 | — | — | CN | disclosed |
| CN-105541801-A | Method for synthesizing EZH2 methyltransferase inhibitor GSK126 | UNIV CHANGZHOU | 2016-05-04 | — | — | CN | disclosed |
| CN-103857681-A | Novel macrocycles as factor XIA inhibitors | BRISTOL MYERS SQUIBB CO | 2014-06-11 | — | — | CN | disclosed |
| CN-102229562-B | Novel 1-2-dihydroquinoline derivative having glucocorticoid receptor binding activity | SANTEN PHARMACEUTICAL CO LTD | 2013-11-13 | — | — | CN | disclosed |
| CN-103209960-A | Sulfonamide compounds useful as CYP17 inhibitors | BRISTOL MYERS SQUIBB CO | 2013-07-17 | — | — | CN | disclosed |
| CN-103002735-A | Modulators of 5-ht receptors and methods of use thereof | ABBVI CO | 2013-03-27 | — | — | CN | disclosed |
| US-7285664-B2 | Heterocyclic or benzenic derivatives of lipoic acid, their preparation and their use as medicaments | S.C.R.A.S. SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (FR) | 2007-10-23 | — | — | US | disclosed |
| US-20050227991-A1 | New heterocyclic or benzenic derivatives of lipoic acid, their preparation and their use as medicaments | IPSEN PHARMA S.A.S. (FR) | 2005-10-13 | — | — | US | disclosed |
| US-6936715-B2 | Lipoic acid heterocyclic or benzene derivatives, preparation and use thereof as medicines | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (FR) | 2005-08-30 | — | — | US | disclosed |
| US-20030105107-A1 | Novel lipoic acid heterocyclic or benzene derivatives, preparation and use thereof as medicines | IPSEN PHARMA S.A.S. (FR) | 2003-06-05 | — | — | US | disclosed |
| WO-2002020630-A1 | PROCESS FOR THE PREPARATION OF GLYCEROL-BASED CROSSLINKED POLYMERIC GELS | LIPAL BIOCHEMICALS (CH) | 2002-03-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030105107-A1 | Novel lipoic acid heterocyclic or benzene derivatives, preparation and use thereof as medicines | LTC4S, LPO, COASY | NFE2L2 191/4885FBP1 924/4885VCP 2409/4885 |
| US-20050227991-A1 | New heterocyclic or benzenic derivatives of lipoic acid, their preparation and their use as medicaments | LPO, LTC4S, BBOX1 | NFE2L2 184/4885FBP1 970/4885VCP 2743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.