Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 10/20 | 0.81 |
| ▸ | PGR | P06401 | 7/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.81 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.81 |
| ▸ | LMNA | P02545 | 3/20 | 0.81 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.81 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.81 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.81 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.81 |
| ▸ | IL5 | P05113 | 1/20 | 0.81 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.81 |
| ▸ | AR | P10275 | 1/20 | 0.81 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.81 |
| ▸ | MMP9 | P14780 | 1/20 | 0.81 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.81 |
| ▸ | THPO | P40225 | 1/20 | 0.81 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.81 |
| ▸ | BLM | P54132 | 1/20 | 0.81 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21569983 | 0.94 | NR3C1 (0.79) | NR3C1PGRCYP3A4HIF1ALMNA | |
| SCHEMBL27072506 | 0.94 | NR3C1 (0.79) | NR3C1PGRCYP3A4HIF1ALMNA | |
| SCHEMBL7735898 | 0.93 | ALDH1A1 (0.84) | NR3C1PGRCYP3A4HIF1ALMNA | |
| SCHEMBL17151413 | 0.93 | ALDH1A1 (0.84) | NR3C1PGRCYP3A4HIF1ALMNA | |
| SCHEMBL7751385 | 0.93 | ALDH1A1 (0.84) | NR3C1PGRCYP3A4HIF1ALMNA | |
| SCHEMBL4448853 | 0.93 | NR3C1 (0.82) | NR3C1PGRCYP3A4HIF1ALMNA | |
| SCHEMBL14965919 | 0.93 | NR3C1 (0.77) | NR3C1PGRCYP3A4HIF1ALMNA | |
| SCHEMBL21153755 | 0.93 | NR3C1 (0.77) | NR3C1PGRCYP3A4HIF1ALMNA | |
| SCHEMBL30987798 | 0.93 | NR3C1 (0.77) | NR3C1PGRCYP3A4HIF1ALMNA | |
| SCHEMBL21152598 | 0.93 | NR3C1 (0.77) | NR3C1PGRCYP3A4HIF1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110650959-B | Therapeutic compounds and compositions and methods of use thereof | 豪夫迈·罗氏有限公司 | 2023-04-18 | — | — | CN | disclosed |
| CN-115667242-A | Tetrahydroisoquinoline compounds as NRF2 activators | 希四克斯探索有限公司 | 2023-01-31 | — | — | CN | disclosed |
| CN-115361989-A | Inhalation device system | 索芙特海尔公司 | 2022-11-18 | — | — | CN | disclosed |
| CN-111465700-A | Water soluble cannabinoid compounds and material compositions in yeast and plant cell suspension cultures | 特征生物科学公司 | 2020-07-28 | — | — | CN | disclosed |
| CN-110678467-A | Therapeutic compounds and compositions and methods of use thereof | 豪夫迈·罗氏有限公司 | 2020-01-10 | — | — | CN | disclosed |
| CN-110650959-A | Therapeutic compounds and compositions and methods of use thereof | 豪夫迈·罗氏有限公司 | 2020-01-03 | — | — | CN | disclosed |
| US-20070166364-A1 | Transdermal Therapeutic System | BEIER CORNELIA | 2007-07-19 | — | — | US | disclosed |
| US-7220473-B2 | Storage stability | HEXAL AG (DE) | 2007-05-22 | — | — | US | disclosed |
| US-20040047901-A1 | Storage stability | HEXAL AG (DE) | 2004-03-11 | — | — | US | disclosed |