Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.45 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5381943 | 0.94 | SMN1; SMN2 (0.50) | GAASMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL5376873 | 0.88 | PTGDR2 (0.46) | GAASMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL5377146 | 0.82 | LTB4R (0.44) | GAASMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL5376726 | 0.82 | GAA (0.79) | GAASMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL5376722 | 0.82 | GAA (0.79) | GAASMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL5374881 | 0.81 | LTB4R (0.47) | GAASMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL5397126 | 0.81 | GAA (0.61) | GAASMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL5382578 | 0.79 | ALDH1A1 (0.47) | GAASMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL5380793 | 0.79 | FFAR1 (0.52) | MAPT | |
| SCHEMBL5378962 | 0.78 | KMT2A (0.64) | GAALMNAKMT2APKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179823-B1 | 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-20 | — | — | US | disclosed |