Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2628773 | 0.87 | TRPM8 (0.58) | TRPM8EPHX1P2RX4ALDH1A1HPGD | |
| SCHEMBL4820315 | 0.84 | TRPM8 (0.55) | TRPM8EPHX1P2RX4ALDH1A1KDM4E | |
| SCHEMBL2628761 | 0.80 | TRPM8 (0.58) | TRPM8EPHX1P2RX4ALDH1A1HPGD | |
| SCHEMBL4812089 | 0.80 | P2RX4 (0.61) | TRPM8EPHX1P2RX4ALDH1A1HPGD | |
| SCHEMBL2628771 | 0.79 | TRPM8 (0.57) | TRPM8EPHX1P2RX4ALDH1A1TRPV1 | |
| SCHEMBL5442957 | 0.79 | TRPM8 (0.73) | TRPM8EPHX1TRPV1 | |
| SCHEMBL14564501 | 0.79 | TRPM8 (0.73) | TRPM8EPHX1TRPV1 | |
| SCHEMBL5391878 | 0.78 | TRPM8 (0.55) | TRPM8EPHX1P2RX4TRPV1 | |
| SCHEMBL4817890 | 0.78 | TRPM8 (0.73) | TRPM8EPHX1P2RX4HPGDKCNA5 | |
| SCHEMBL10073491 | 0.78 | TRPM8 (0.73) | TRPM8EPHX1P2RX4HPGDKCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070053834-A1 | Radioligands for the TRP-M8 receptor and methods therewith | WEI EDWARD T | 2007-03-08 | — | — | US | disclosed |
| US-7169377-B2 | Radioligands for the TRP-M8 receptor and methods therewith | WEI EDWARD T | 2007-01-30 | — | — | US | disclosed |
| WO-2005039649-A1 | RADIOLIGANDS FOR THE TRP-M8 RECEPTOR AND METHODS THEREWITH | PAGET, HUGH, C., E. (GB) | 2005-05-06 | — | — | WO | disclosed |
| US-20050084447-A1 | Radioligands for the TRP-M8 receptor and methods therewith | WEI EDWARD T (US) | 2005-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050084447-A1 | Radioligands for the TRP-M8 receptor and methods therewith | TRPM8, GPR68, OPRL1 | TRPM8 1/4885EPHX1 4381/4885P2RX4 266/4885 |
| US-20070053834-A1 | Radioligands for the TRP-M8 receptor and methods therewith | GPR68, TRPM8, OPRL1 | TRPM8 2/4885EPHX1 4778/4885P2RX4 355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.