Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.73 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.45 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10073491 | 1.00 | TRPM8 (0.73) | TRPM8EPHX1MAPTHPGDMEN1 | |
| SCHEMBL2628738 | 0.92 | TRPM8 (0.70) | TRPM8EPHX1MAPTHPGDMEN1 | |
| SCHEMBL4886771 | 0.88 | TRPM8 (0.72) | TRPM8EPHX1MAPTHPGDMEN1 | |
| SCHEMBL10073486 | 0.88 | TRPM8 (0.75) | TRPM8EPHX1MAPTHPGDMEN1 | |
| SCHEMBL2628672 | 0.88 | TRPM8 (0.75) | TRPM8EPHX1MAPTHPGDMEN1 | |
| SCHEMBL4817319 | 0.88 | TRPM8 (0.75) | TRPM8EPHX1MAPTHPGDMEN1 | |
| SCHEMBL4820732 | 0.88 | TRPM8 (0.75) | TRPM8EPHX1MAPTHPGDMEN1 | |
| SCHEMBL2628758 | 0.86 | TRPM8 (0.73) | TRPM8EPHX1MAPTHPGDMEN1 | |
| SCHEMBL2628747 | 0.86 | TRPM8 (0.73) | TRPM8EPHX1MAPTHPGDMEN1 | |
| SCHEMBL14593913 | 0.86 | TRPM8 (0.73) | TRPM8EPHX1MAPTHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106659656-B | Oral composition | 狮王株式会社 | 2020-01-10 | — | — | CN | claimed |
| CN-106659656-B | Oral composition | 狮王株式会社 | 2020-01-10 | — | — | CN | disclosed |
| US-8426643-B2 | Synthesis of cyclohexane derivatives useful as sensates in consumer products | THE PROCTER & GAMBLE COMPANY (US) | 2013-04-23 | — | — | US | disclosed |
| US-20100076080-A1 | Synthesis of Cyclohexane Derivatives Useful as Sensates in Consumer Products | THE PROCTER & GAMBLE COMPANY | 2010-03-25 | — | — | US | disclosed |
| US-7417048-B2 | Aryl-substituted derivatives of cycloalkyl and branched chain alkyl carboxylic acids useful as antinociceptive drugs for peripheral targets | WEI EDWARD T | 2008-08-26 | — | — | US | disclosed |
| US-20070053834-A1 | Radioligands for the TRP-M8 receptor and methods therewith | WEI EDWARD T | 2007-03-08 | — | — | US | disclosed |
| US-7169377-B2 | Radioligands for the TRP-M8 receptor and methods therewith | WEI EDWARD T | 2007-01-30 | — | — | US | disclosed |
| US-20050187211-A1 | N-arylsalkyl-carboxamide compositions and methods | WEI EDWARD T (US) | 2005-08-25 | — | — | US | disclosed |
| US-20050159394-A1 | Aryl-substituted derivatives of cycloalkyl and branched chain alkyl carboxylic acids useful as antinociceptive drugs for peripheral targets | WEI EDWARD T (US) | 2005-07-21 | — | — | US | disclosed |
| US-20050084447-A1 | Radioligands for the TRP-M8 receptor and methods therewith | WEI EDWARD T (US) | 2005-04-21 | — | — | US | disclosed |
| EP-1311158-B1 | COMPOSITION HAVING INSECT REPELLENT CHARACTERISTICS | GIVAUDAN SA (CH) | 2004-08-11 | — | — | EP | disclosed |
| US-20040028714-A1 | Composition having insect repellent characteristics | GIVAUDAN SA (CH) | 2004-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050084447-A1 | Radioligands for the TRP-M8 receptor and methods therewith | TRPM8, GPR68, OPRL1 | TRPM8 1/4885EPHX1 4381/4885MAPT 1942/4885 |
| US-20050187211-A1 | N-arylsalkyl-carboxamide compositions and methods | OPRL1, TRPV1, TRPA1 | TRPM8 13/4885EPHX1 1355/4885MAPT 4273/4885 |
| US-20070053834-A1 | Radioligands for the TRP-M8 receptor and methods therewith | GPR68, TRPM8, OPRL1 | TRPM8 2/4885EPHX1 4778/4885MAPT 1052/4885 |
| US-20050159394-A1 | Aryl-substituted derivatives of cycloalkyl and branched chain alkyl carboxylic acids useful as antinociceptive drugs for peripheral targets | OPRL1, OPRK1, OPRD1 | TRPM8 588/4885EPHX1 3744/4885MAPT 3501/4885 |
| US-20100076080-A1 | Synthesis of Cyclohexane Derivatives Useful as Sensates in Consumer Products | NISCH, TRPM4, TRPM8 | TRPM8 3/4885EPHX1 528/4885MAPT 1429/4885 |
| US-20040028714-A1 | Composition having insect repellent characteristics | SUV39H1, PNMT, SUV39H2 | TRPM8 36/4885EPHX1 690/4885MAPT 201/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.