Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 8/20 | 0.51 |
| ▸ | ACHE | P22303 | 7/20 | 0.51 |
| ▸ | BACE1 | P56817 | 7/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KAT2B | Q92831 | 3/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7814261 | 0.85 | ACSS2 (0.42) | CYP1A2CYP3A4CYP2D6KAT2BCHRM2 | |
| SCHEMBL7810586 | 0.85 | ACSS2 (0.42) | CYP1A2CYP3A4CYP2D6KAT2BCHRM2 | |
| SCHEMBL7814203 | 0.84 | CCR1 (0.44) | CYP3A4CYP2D6CHRM2CHRM1CHRM3 | |
| SCHEMBL7817778 | 0.84 | CYP2D6 (0.42) | CYP1A2CYP3A4CYP2D6CHRM2CHRM1 | |
| SCHEMBL7814202 | 0.84 | CCR1 (0.44) | CYP3A4CYP2D6CHRM2CHRM1CHRM3 | |
| SCHEMBL13761638 | 0.81 | ALDH1A1 (0.60) | BCHEACHEBACE1CYP1A2CYP3A4 | |
| SCHEMBL16386020 | 0.77 | CYP1A2 (0.62) | BCHEACHEBACE1CYP1A2CYP3A4 | |
| SCHEMBL31014995 | 0.76 | BCHE (0.58) | BCHEACHEBACE1CYP1A2CYP3A4 | |
| SCHEMBL16083118 | 0.76 | CYP1A2 (0.60) | BCHEACHEBACE1CYP1A2CYP3A4 | |
| SCHEMBL2730825 | 0.76 | CYP1A2 (0.60) | BCHEACHEBACE1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7199147-B2 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2007-04-03 | — | — | US | disclosed |
| US-20040138286-A1 | Rho kinase inhibitors | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2004-07-15 | — | — | US | disclosed |
| EP-1403255-A1 | Rho KINASE INHIBITORS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2004-03-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138286-A1 | Rho kinase inhibitors | ROCK1, ROCK2, ARHGDIA | BCHE 3653/4885ACHE 4187/4885BACE1 3769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.