SCHEMBL5402610

SCHEMBL5402610

COc1ccccc1C(=O)NS(=O)(=O)c1ccc(N(C)C(N)=O)cc1

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.52
FLT1 P17948 5/20 0.50
FLT4 P35916 5/20 0.50
KDR P35968 5/20 0.50
CTSD P07339 1/20 0.48
POLB P06746 2/20 0.47
RXFP1 Q9HBX9 1/20 0.47
KAT6A Q92794 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
THRB P10828 1/20 0.45
CA1 P00915 1/20 0.45
CA2 P00918 1/20 0.45
CA9 Q16790 1/20 0.45
KDM4E B2RXH2 1/20 0.45
MAPK1 P28482 1/20 0.45
ALDH1A1 P00352 1/20 0.44
RAB9A P51151 1/20 0.44
HPGD P15428 1/20 0.43
STAT3 P40763 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9069043 0.87 GAA (0.51) GAAFLT1FLT4KDRCTSD
SCHEMBL15495162 0.83 RXFP1 (0.60) GAAFLT1FLT4KDRPOLB
SCHEMBL18803129 0.83 POLB (0.64) GAAFLT1FLT4KDRCTSD
SCHEMBL7797528 0.82 GAA (0.59) GAAFLT1FLT4KDRCTSD
SCHEMBL9414560 0.82 POLB (0.68) GAAFLT1FLT4KDRCTSD
SCHEMBL16244081 0.82 KDM4E (0.62) GAAFLT1FLT4KDRCTSD
SCHEMBL28301129 0.81 GAA (0.50) GAAFLT1FLT4KDRCTSD
SCHEMBL13754035 0.81 GAA (0.54) GAAFLT1FLT4KDRCTSD
SCHEMBL871964 0.80 HPGD (0.57) GAAFLT1FLT4KDRCTSD
SCHEMBL20492767 0.80 GAA (0.51) GAAFLT1FLT4KDRCTSD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7202196-B2 Selective herbicide comprising a tetrazolinone derivative BAYER CROPSCIENCE AG (DE) 2007-04-10 US claimed
EP-1221848-B1 SELECTIVE HERBICIDES ON THE BASIS A N-ARYL-TRIAZOLINEONE BAYER CROPSCIENCE AG (DE) 2006-01-25 EP claimed
US-20050085388-A1 Selective herbicide comprising a tetrazolinone derivative BAYER CROPSCIENCE AG (DE) 2005-04-21 US claimed
US-6849578-B1 Selective herbicides based on 2,6-disubstituted pyridine derivatives BAYER AKTIENGESELLSCHAFT (DE) 2005-02-01 US claimed
US-6841517-B1 Selective herbicides on basis of N-aryl-triazoline(thi)ones BAYER AKTIENGESELLSCHAFT (DE) 2005-01-11 US claimed
EP-1221844-B1 SELECTIVE HERBICIDES BASED ON PYRIMIDINE-DERIVATIVES BAYER CROPSCIENCE AG (DE) 2004-08-18 EP claimed
EP-1423010-A2 SELECTIVE HERBICIDE COMPRISING A TETRAZOLINONE DERIVATIVE Bayer CropScience AG (DE) 2004-06-02 EP claimed
EP-1351571-A2 SELECTIVE HERBICIDES BASED UPON 2,6-DISUBSTITUTED PYRIDINE DERIVATIVES Bayer CropScience AG (DE) 2003-10-15 EP claimed
WO-2003020035-A2 SELECTIVE HERBICIDE COMPRISING A TETRAZOLINONE DERIVATIVE BAYER CROPSCIENCE AG (DE) 2003-03-13 WO claimed
EP-1221848-A1 SELECTIVE HERBICIDES ON THE BASIS OF N-ARYL-TRIAZOLINE(THI)ONES Bayer Aktiengesellschaft (DE) 2002-07-17 EP claimed
EP-1211941-A1 SELECTIVE HERBICIDES ON THE BASIS OF A SUBSTITUTED PHENYLSULFONYLAMINOCARBONYLTRIAZOLINONE AND SAFENERS Bayer Aktiengesellschaft (DE) 2002-06-12 EP claimed
WO-2001035740-A2 SELECTIVE HERBICIDES BASED UPON 2,6-DISUBSTITUTED PYRIDINE DERIVATIVES BAYER AKTIENGESELLSCHAFT (DE) 2001-05-25 WO claimed
WO-2001022819-A1 SELECTIVE HERBICIDES ON THE BASIS OF N-ARYL-TRIAZOLINE(THI)ONES BAYER AKTIENGESELLSCHAFT (DE) 2001-04-05 WO claimed
WO-2001015533-A1 SELECTIVE HERBICIDES ON THE BASIS OF A SUBSTITUTED PHENYLSULFONYLAMINOCARBONYLTRIAZOLINONE AND SAFENERS BAYER AKTIENGESELLSCHAFT (DE) 2001-03-08 WO claimed
US-5858920-A SYNERGISTIC MIXTURE; PLANT SAFENING AGENT BAYER AKTIENGESELLSCHAFT (DE) 1999-01-12 US claimed
US-7202196-B2 Selective herbicide comprising a tetrazolinone derivative BAYER CROPSCIENCE AG (DE) 2007-04-10 US disclosed
EP-1221848-B1 SELECTIVE HERBICIDES ON THE BASIS A N-ARYL-TRIAZOLINEONE BAYER CROPSCIENCE AG (DE) 2006-01-25 EP disclosed
WO-2001015533-A1 SELECTIVE HERBICIDES ON THE BASIS OF A SUBSTITUTED PHENYLSULFONYLAMINOCARBONYLTRIAZOLINONE AND SAFENERS BAYER AKTIENGESELLSCHAFT (DE) 2001-03-08 WO disclosed
WO-2001015533-A1 SELECTIVE HERBICIDES ON THE BASIS OF A SUBSTITUTED PHENYLSULFONYLAMINOCARBONYLTRIAZOLINONE AND SAFENERS BAYER AKTIENGESELLSCHAFT (DE) 2001-03-08 WO disclosed
US-5858920-A SYNERGISTIC MIXTURE; PLANT SAFENING AGENT BAYER AKTIENGESELLSCHAFT (DE) 1999-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050085388-A1 Selective herbicide comprising a tetrazolinone derivative DDT, DYRK4, DYRK3 GAA 531/4885FLT1 3793/4885FLT4 3384/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.