SCHEMBL28301129

SCHEMBL28301129

COc1ccccc1C(=O)NS(=O)(=O)c1ccc(N(C=O)C(C)C)cc1

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.50
FLT1 P17948 3/20 0.48
FLT4 P35916 3/20 0.48
KDR P35968 3/20 0.48
POLB P06746 2/20 0.45
RXFP1 Q9HBX9 1/20 0.45
KAT6A Q92794 1/20 0.45
THRB P10828 1/20 0.43
ALDH1A1 P00352 3/20 0.43
HPGD P15428 2/20 0.43
CTSD P07339 1/20 0.43
RAB9A P51151 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
STAT3 P40763 1/20 0.41
KDM4E B2RXH2 1/20 0.41
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA9 Q16790 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27573936 0.86 GAA (0.50) GAAFLT1FLT4KDRPOLB
SCHEMBL5402610 0.81 GAA (0.52) GAAFLT1FLT4KDRPOLB
SCHEMBL27859768 0.81 GAA (0.47) GAAFLT1FLT4KDRPOLB
SCHEMBL9069043 0.81 GAA (0.51) GAAFLT1FLT4KDRPOLB
Formamide SCHEMBL28301130 0.81 FLT1 (0.52) GAAFLT1FLT4KDRPOLB
SCHEMBL9414560 0.80 POLB (0.68) GAAFLT1FLT4KDRPOLB
SCHEMBL16244081 0.80 KDM4E (0.62) GAAFLT1FLT4KDRPOLB
SCHEMBL125423 0.79 L3MBTL1 (0.54) GAAFLT1FLT4KDRPOLB
SCHEMBL20492767 0.78 GAA (0.51) GAAFLT1FLT4KDRPOLB
SCHEMBL7797528 0.78 GAA (0.59) GAAFLT1FLT4KDRPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109890796-A Weeding pyridazinone compound 先正达参股股份有限公司 2019-06-14 CN disclosed