Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5403021 | 1.00 | KDM4E (0.39) | KDM4EALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL5446806 | 0.86 | ABCC1 (0.34) | KDM4EALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL5446807 | 0.86 | ABCC1 (0.34) | KDM4EALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL5731448 | 0.82 | ALDH1A1 (0.33) | ALDH1A1KMT2ASMN1; SMN2MEN1HPGD | |
| SCHEMBL2431710 | 0.82 | ALDH1A1 (0.44) | ALDH1A1KMT2ASMN1; SMN2MEN1TDP1 | |
| SCHEMBL2431713 | 0.82 | ALDH1A1 (0.44) | ALDH1A1KMT2ASMN1; SMN2MEN1TDP1 | |
| SCHEMBL5731426 | 0.81 | ALOX5 (0.34) | KDM4EALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL5436173 | 0.80 | OPRK1 (0.35) | KDM4EALDH1A1KMT2AHPGDTSHR | |
| SCHEMBL5436177 | 0.80 | OPRK1 (0.35) | KDM4EALDH1A1KMT2AHPGDTSHR | |
| SCHEMBL5448010 | 0.80 | KCNB1 (0.34) | ALDH1A1KMT2ASMN1; SMN2MEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007088148-A1 | DERIVATIVES OF THIOPHENE CARBOXILIC ACID AS ANTIVIRAL AGENT | SMITHKLINE BEECHAM CORPORATION (US) | 2007-08-09 | — | — | WO | disclosed |
| US-20070099929-A1 | Substituted thiophenes | AICURIS GMBH & CO. KG (DE) | 2007-05-03 | — | — | US | disclosed |
| US-20070099929-A1 | Substituted thiophenes | AICURIS GMBH & CO. KG (DE) | 2007-05-03 | — | — | US | disclosed |
| US-20070099929-A1 | Substituted thiophenes | AICURIS GMBH & CO. KG (DE) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099929-A1 | Substituted thiophenes | TPMT, HAVCR2, MTAP | KDM4E 2012/4885ALDH1A1 1246/4885KMT2A 3784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.