SCHEMBL5403177

SCHEMBL5403177

CCOC(=O)C(N)=NOC(=O)[C@H](CCCC1CCCCC1)CC(=O)OC(C)(C)C

nearest known ligand 0.36

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
BMP1 P13497 7/20 0.36
MMP2 P08253 1/20 0.36
METAP2 P50579 1/20 0.35
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
F7 P08709 1/20 0.34
PDE4A P27815 1/20 0.32
PDE4B Q07343 1/20 0.32
PDE4C Q08493 1/20 0.32
PDE4D Q08499 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
PPARG P37231 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5403174 1.00 BMP1 (0.36) BMP1MMP2METAP2MEN1KMT2A
SCHEMBL6430229 0.89 SMN1; SMN2 (0.34) BMP1MMP2MEN1KMT2APDE4A
SCHEMBL6430228 0.89 SMN1; SMN2 (0.34) BMP1MMP2MEN1KMT2APDE4A
SCHEMBL5759687 0.88 BMP1 (0.37) BMP1MMP2METAP2MEN1KMT2A
SCHEMBL5759691 0.88 BMP1 (0.37) BMP1MMP2METAP2MEN1KMT2A
SCHEMBL6872894 0.79 BMP1 (0.37) BMP1MMP2MEN1KMT2APDE4A
SCHEMBL5409828 0.78 BMP1 (0.36) BMP1MMP2MEN1KMT2APDE4A
SCHEMBL6872622 0.78 SMN1; SMN2 (0.36) BMP1MMP2MEN1KMT2APDE4A
SCHEMBL6872619 0.78 SMN1; SMN2 (0.36) BMP1MMP2MEN1KMT2APDE4A
SCHEMBL5416055 0.77 FKBP1A (0.41) MEN1KMT2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7214694-B2 3-ox(adi)azolylpropanohydroxamic acids useful as procollagen C-proteinase inhibitors PFIZER INC (US) 2007-05-08 US disclosed
US-20040142986-A1 3-ox(adi)azolylpropanohydroxamic acids useful as procollagen C-proteinase inhibitors DATTA USA (GB) 2004-07-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040142986-A1 3-ox(adi)azolylpropanohydroxamic acids useful as procollagen C-proteinase inhibitors ALPI, TIMP3, MMP1 BMP1 376/4885MMP2 22/4885METAP2 532/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.