Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 13/20 | 1.00 |
| ▸ | CDK1 | P06493 | 4/20 | 0.79 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.79 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.79 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.79 |
| ▸ | GSK3B | P49841 | 16/20 | 0.78 |
| ▸ | CDK2 | P24941 | 4/20 | 0.66 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.66 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.66 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.66 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | FLT4 | P35916 | 1/20 | 0.66 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.66 |
| ▸ | CLK2 | P49760 | 1/20 | 0.66 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.66 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.66 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.66 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10059342 | 0.89 | GSK3A (1.00) | GSK3ACDK1CCNB2CCNB1CCNB3 | |
| Hydrochloric Acid SCHEMBL5403658 | 0.87 | GSK3B (0.98) | GSK3ACDK1CCNB2CCNB1CCNB3 | |
| Hydrochloric Acid SCHEMBL5395087 | 0.81 | GSK3A (0.68) | GSK3ACDK1CCNB2CCNB1CCNB3 | |
| SCHEMBL5829062 | 0.81 | GSK3B (1.00) | GSK3ACDK1CCNB2CCNB1CCNB3 | |
| SCHEMBL5390676 | 0.81 | GSK3B (0.69) | GSK3ACDK1GSK3BCDK2LIMK1 | |
| SCHEMBL1461843 | 0.77 | GSK3B (1.00) | GSK3ACDK1GSK3BCDK2 | |
| SCHEMBL4493121 | 0.77 | GSK3B (1.00) | GSK3AGSK3B | |
| SCHEMBL31060453 | 0.77 | GSK3B (1.00) | GSK3AGSK3B | |
| SCHEMBL7255560 | 0.76 | GSK3A (0.78) | GSK3ACDK1CCNB2CCNB1CCNB3 | |
| SCHEMBL7155632 | 0.76 | GSK3B (0.62) | GSK3ACDK1CCNB2CCNB1CCNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7297792-B2 | Pyrazolopyridines and pyrazolopyridazines as antidiabetics | SMITHKLINE BEECHAM CORPORATION (US) | 2007-11-20 | — | — | US | disclosed |
| US-20060223800-A1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIDAZINES ADN ANTIDIABETICS | GARLAND STEPHEN | 2006-10-05 | — | — | US | disclosed |
| US-7109199-B2 | Pyrazolopyridines and pyrazolopyridazines as antidiabetics | SMITHKLINE BEECHAM CORPORATION (US) | 2006-09-19 | — | — | US | disclosed |
| US-20040019052-A1 | Pyrazolopyridines and pyrazolopyridazines as antidabetics | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060223800-A1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIDAZINES ADN ANTIDIABETICS | ADK, PDXK, GPR119 | GSK3A 1785/4885CDK1 779/4885CCNB2 2298/4885 |
| US-20040019052-A1 | Pyrazolopyridines and pyrazolopyridazines as antidabetics | PDXK, GCK, IAPP | GSK3A 3027/4885CDK1 1444/4885CCNB2 3128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.