Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.60 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.53 |
| ▸ | RRM1 | P23921 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5404631 | 1.00 | PIM1 (0.60) | PIM1PIM3KDM4EHPGDHTT | |
| SCHEMBL5415543 | 0.85 | PIM1 (0.81) | PIM1PIM3KDM4EHPGDHTT | |
| SCHEMBL27490067 | 0.83 | KDM4E (0.59) | PIM1PIM3KDM4EHPGDHTT | |
| SCHEMBL14070635 | 0.78 | NR4A2 (0.53) | PIM1PIM3KDM4EHPGDHTT | |
| SCHEMBL14072599 | 0.78 | NR4A2 (0.53) | PIM1PIM3KDM4EHPGDHTT | |
| SCHEMBL29264058 | 0.77 | PIM1 (0.56) | PIM1PIM3KDM4EHPGDHTT | |
| SCHEMBL30561991 | 0.77 | PIM1 (0.56) | PIM1PIM3KDM4EHPGDHTT | |
| SCHEMBL29264055 | 0.77 | PIM1 (0.56) | PIM1PIM3KDM4EHPGDHTT | |
| SCHEMBL17798752 | 0.77 | NR4A2 (0.68) | PIM1PIM3KDM4EHPGDHTT | |
| SCHEMBL19420159 | 0.76 | PIM1 (0.55) | PIM1PIM3KDM4EHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312342-B2 | Process for the preparation of (3-cyano-1h-indol-7-yl) (4-(4-fluorophenethyl) piperazin-1-yl)-methanone and salts thereof | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2007-12-25 | — | — | US | disclosed |
| EP-1353906-B1 | PROCESS FOR THE PREPARATION OF (3-CYANO-1H-INDOL-7-YL)(4-(4-FLUOROPHENETHYL)PIPERAZIN-1-YL)-METHANONE AND SALTS THEREOF | MERCK PATENT GMBH (DE) | 2004-06-23 | — | — | EP | disclosed |
| US-20040063723-A1 | Process for the preparation of (3-cyano-1h-indol-7-yl) (4-(4-fluorophenethyl) piperazin-1-yl)- methanone and salts thereof | MERCK PATENT GMBH (DE) | 2004-04-01 | — | — | US | disclosed |
| EP-1353906-A1 | PROCESS FOR THE PREPARATION OF (3-CYANO-1H-INDOL-7-YL)(4-(4-FLUOROPHENETHYL)PIPERAZIN-1-YL)-METHANONE AND SALTS THEREOF | MERCK PATENT GmbH (DE) | 2003-10-22 | — | — | EP | disclosed |
| WO-2002059092-A1 | PROCESS FOR THE PREPARATION OF (3-CYANO-1H-INDOL-7-YL)(4-(4-FLUOROPHENETHYL)PIPERAZIN-1-YL)-METHANONE AND SALTS THEREOF | MERCK PATENT GMBH (DE) | 2002-08-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063723-A1 | Process for the preparation of (3-cyano-1h-indol-7-yl) (4-(4-fluorophenethyl) piperazin-1-yl)- methanone and salts thereof | TPH1, TPH2, IDO1 | PIM1 597/4885PIM3 847/4885KDM4E 226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.