Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | EIF4E | P06730 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.38 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.38 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.36 |
| ▸ | MASP2 | O00187 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | FBP1 | P09467 | 1/20 | 0.33 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6191439 | 0.80 | EIF4E (0.35) | ALDH1A1EIF4ECYP3A4HIF1ATDP1 | |
| SCHEMBL6232168 | 0.77 | ALDH1A1 (0.36) | ALDH1A1CYP3A4TSHRHIF1ATDP1 | |
| SCHEMBL3535919 | 0.76 | ALDH1A1 (0.53) | ALDH1A1CYP3A4HPGDHIF1ATDP1 | |
| SCHEMBL15868446 | 0.75 | ALDH1A1 (0.58) | ALDH1A1EIF4ECYP3A4HPGDALOX15 | |
| SCHEMBL6194171 | 0.75 | PTGS2 (0.40) | ALDH1A1EIF4ETDP1FBP1MAPT | |
| SCHEMBL6192872 | 0.75 | FBP1 (0.40) | ALDH1A1EIF4ETDP1FBP1MAPT | |
| SCHEMBL6683239 | 0.73 | HTR7 (0.42) | ALDH1A1CYP3A4TDP1LMNASCN2A | |
| SCHEMBL5150349 | 0.73 | TSHR (0.48) | ALDH1A1ALOX15TSHRTDP1LMNA | |
| SCHEMBL3556690 | 0.73 | ALDH1A1 (0.34) | ALDH1A1CYP3A4HPGDALOX15TSHR | |
| SCHEMBL6191701 | 0.72 | PTGS2 (0.40) | ALDH1A1EIF4EHPGDTSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007518825-A | — | — | 2007-07-12 | — | — | JP | claimed |
| EP-1706399-A1 | POLYETHYLENE GLYCOL CONJUGATES OF HETEROCYCLOALKYL CARBOXAMIDO PROPANOIC ACIDS | Elan Pharmaceuticals, Inc. (US) | 2006-10-04 | — | — | EP | claimed |
| WO-2005070921-A1 | POLYETHYLENE GLYCOL CONJUGATES OF HETEROCYCLOALKYL CARBOXAMIDO PROPANOIC ACIDS | ELAN PHARMACEUTICALS, INC. (US) | 2005-08-04 | — | — | WO | claimed |