Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.49 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5409892 | 0.85 | ALDH1A1 (0.54) | DYRK1ACLEC4MHTR2AHTR2CDRD4 | |
| SCHEMBL5421162 | 0.82 | CLEC4M (0.66) | DYRK1ACLEC4MHTR2AHTR2CDRD4 | |
| SCHEMBL5417964 | 0.80 | CLEC4M (0.46) | CLEC4MHTTKDM4EALDH1A1LMNA | |
| SCHEMBL5414352 | 0.80 | CLEC4M (0.46) | CLEC4MHTTKDM4EALDH1A1LMNA | |
| SCHEMBL5416790 | 0.80 | NR4A2 (0.49) | CLEC4MHTTKDM4EALDH1A1LMNA | |
| SCHEMBL5414753 | 0.79 | DYRK1A (0.58) | DYRK1AHTR2AHTR2CDRD4SLC6A2 | |
| SCHEMBL5409978 | 0.77 | PIM3 (0.60) | CLEC4MHTTKDM4EALDH1A1LMNA | |
| SCHEMBL5404115 | 0.76 | ALDH1A1 (0.49) | DYRK1ACLEC4MHTR2AHTR2CDRD4 | |
| SCHEMBL27469298 | 0.75 | LMNA (0.43) | KDM4EALDH1A1LMNAMAPTHSD17B10 | |
| SCHEMBL27641139 | 0.73 | MAPT (0.39) | KDM4EALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312342-B2 | Process for the preparation of (3-cyano-1h-indol-7-yl) (4-(4-fluorophenethyl) piperazin-1-yl)-methanone and salts thereof | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2007-12-25 | — | — | US | claimed |
| US-7312342-B2 | Process for the preparation of (3-cyano-1h-indol-7-yl) (4-(4-fluorophenethyl) piperazin-1-yl)-methanone and salts thereof | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2007-12-25 | — | — | US | disclosed |
| CN-1213029-C | Process for the preparation of (3-cyano-1H-indol-7-yl) (4-(4-fluorophenethyl)piperazin-1-yl)-methanone and salts thereof | MERCH PATENT GMBH (DE) | 2005-08-03 | — | — | CN | disclosed |
| EP-1353906-B1 | PROCESS FOR THE PREPARATION OF (3-CYANO-1H-INDOL-7-YL)(4-(4-FLUOROPHENETHYL)PIPERAZIN-1-YL)-METHANONE AND SALTS THEREOF | MERCK PATENT GMBH (DE) | 2004-06-23 | — | — | EP | disclosed |
| CN-1487923-A | Process for the preparation of (3-cyano-1H-indol-7-yl) (4- (4-fluorophenethyl) piperazin-1-yl) -methanone and salts thereof | Ĭ��ר���ɷ�����˾ | 2004-04-07 | — | — | CN | disclosed |
| US-20040063723-A1 | Process for the preparation of (3-cyano-1h-indol-7-yl) (4-(4-fluorophenethyl) piperazin-1-yl)- methanone and salts thereof | MERCK PATENT GMBH (DE) | 2004-04-01 | — | — | US | disclosed |
| EP-1353906-A1 | PROCESS FOR THE PREPARATION OF (3-CYANO-1H-INDOL-7-YL)(4-(4-FLUOROPHENETHYL)PIPERAZIN-1-YL)-METHANONE AND SALTS THEREOF | MERCK PATENT GmbH (DE) | 2003-10-22 | — | — | EP | disclosed |
| WO-2002059092-A1 | PROCESS FOR THE PREPARATION OF (3-CYANO-1H-INDOL-7-YL)(4-(4-FLUOROPHENETHYL)PIPERAZIN-1-YL)-METHANONE AND SALTS THEREOF | MERCK PATENT GMBH (DE) | 2002-08-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063723-A1 | Process for the preparation of (3-cyano-1h-indol-7-yl) (4-(4-fluorophenethyl) piperazin-1-yl)- methanone and salts thereof | TPH1, TPH2, IDO1 | DYRK1A 1613/4885CLEC4M 4350/4885HTR2A 32/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.