Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A5 | Q9Y345 | 11/20 | 0.60 |
| ▸ | SLC6A9 | P48067 | 11/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6011895 | 0.87 | POLB (0.68) | SLC6A5SLC6A9POLBMAPTMEN1 | |
| SCHEMBL3921046 | 0.86 | SLC6A9 (0.81) | SLC6A5SLC6A9POLBMAPTMEN1 | |
| SCHEMBL27643049 | 0.85 | SLC6A5 (0.58) | SLC6A5SLC6A9POLBMAPTMEN1 | |
| SCHEMBL5394474 | 0.85 | SLC6A9 (0.68) | SLC6A5SLC6A9POLBMAPTMEN1 | |
| SCHEMBL5399449 | 0.84 | SLC6A9 (0.70) | SLC6A5SLC6A9POLBMAPTMEN1 | |
| SCHEMBL6024909 | 0.84 | SLC6A9 (0.70) | SLC6A5SLC6A9POLBMAPTMEN1 | |
| SCHEMBL6011826 | 0.84 | POLB (0.57) | SLC6A5SLC6A9POLBMAPTMEN1 | |
| SCHEMBL6031348 | 0.84 | POLB (0.57) | SLC6A5SLC6A9POLBMAPTMEN1 | |
| SCHEMBL6011857 | 0.84 | SLC6A9 (0.59) | SLC6A5SLC6A9POLBMAPTMEN1 | |
| SCHEMBL27643048 | 0.83 | SLC6A5 (0.59) | SLC6A5SLC6A9POLBMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007505060-A | — | — | 2007-03-08 | — | — | JP | claimed |
| EP-1663232-A1 | 1-(2-AMINO-BENZOYL)-PIPERAZINE DERIVATIVES AS GLYCINE UPTAKE INHIBITORS FOR THE TREATMENT OF PSYCHOSES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-07 | — | — | EP | claimed |
| WO-2005023260-A1 | 1- (2-AMINO-BENZOL) -PIPERAZINE DERIVATIVES AS GLYCINE UPTAKE INHIBITORS FOR THE TREATMENT OF PSYCHOSES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-03-17 | — | — | WO | claimed |
| EP-1663232-A1 | 1-(2-AMINO-BENZOYL)-PIPERAZINE DERIVATIVES AS GLYCINE UPTAKE INHIBITORS FOR THE TREATMENT OF PSYCHOSES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005023260-A1 | 1- (2-AMINO-BENZOL) -PIPERAZINE DERIVATIVES AS GLYCINE UPTAKE INHIBITORS FOR THE TREATMENT OF PSYCHOSES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-03-17 | — | — | WO | disclosed |