Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | SLC6A5 | Q9Y345 | 13/20 | 0.55 |
| ▸ | SLC6A9 | P48067 | 13/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MITF | O75030 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6011895 | 0.89 | POLB (0.68) | POLBMEN1LMNAMAPTMAPK1 | |
| SCHEMBL5394474 | 0.87 | SLC6A9 (0.68) | POLBMEN1LMNAMAPTMAPK1 | |
| SCHEMBL5399449 | 0.86 | SLC6A9 (0.70) | POLBMEN1LMNAMAPTMAPK1 | |
| SCHEMBL6011826 | 0.86 | POLB (0.57) | POLBMEN1LMNAMAPTMAPK1 | |
| SCHEMBL6024909 | 0.86 | SLC6A9 (0.70) | POLBMEN1LMNAMAPTMAPK1 | |
| SCHEMBL6011857 | 0.85 | SLC6A9 (0.59) | POLBMEN1LMNAMAPTMAPK1 | |
| SCHEMBL6024299 | 0.85 | SLC6A9 (0.58) | POLBMEN1LMNAMAPTMAPK1 | |
| SCHEMBL5397289 | 0.84 | SLC6A9 (0.71) | SLC6A5SLC6A9 | |
| SCHEMBL4426478 | 0.84 | SLC6A5 (0.77) | POLBMEN1LMNAMAPTMAPK1 | |
| SCHEMBL5404747 | 0.84 | SLC6A5 (0.60) | POLBMEN1LMNAMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656361-A1 | PIPERAZINE WITH OR-SUBSTITUTED PHENYL GROUP AND THEIR USE AS GLYT1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-05-17 | — | — | EP | disclosed |
| WO-2005014563-A1 | PIPERAZINE WITH OR-SUBSTITUTED PHENYL GROUP AND THEIR USE AS GLYT1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-02-17 | — | — | WO | disclosed |