Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | QPCT | Q16769 | 3/20 | 0.35 |
| ▸ | QPCTL | Q9NXS2 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1286646 | 0.78 | MAPT (0.47) | MAPTKDM4EALDH1A1TDP1APEX1 | |
| SCHEMBL22076879 | 0.74 | MAPT (0.47) | MAPTKDM4EALDH1A1TDP1APEX1 | |
| SCHEMBL10903 | 0.74 | PARP1 (0.56) | MAPTKDM4EALDH1A1TDP1APEX1 | |
| SCHEMBL115965 | 0.74 | PRKCI (0.70) | MAPTKDM4EALDH1A1TDP1APEX1 | |
| SCHEMBL903276 | 0.74 | PARP1 (0.52) | MAPTKDM4EALDH1A1TDP1APEX1 | |
| SCHEMBL4740274 | 0.74 | PARP1 (0.52) | MAPTKDM4EALDH1A1TDP1APEX1 | |
| SCHEMBL10757 | 0.74 | CHEK1 (0.52) | MAPTKDM4EALDH1A1TDP1APEX1 | |
| SCHEMBL1052336 | 0.74 | MAPT (0.47) | MAPTKDM4EALDH1A1TDP1APEX1 | |
| SCHEMBL352025 | 0.74 | LMNA (0.55) | MAPTKDM4EALDH1A1TDP1APEX1 | |
| SCHEMBL2022694 | 0.74 | MAPT (0.42) | MAPTKDM4EALDH1A1TDP1APEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7294624-B2 | Osteoporosis; antiarthritic agents | BRISTOL MYERS SQUIBB COMPANY (US) | 2007-11-13 | — | — | US | disclosed |
| EP-0832091-B1 | C-4' MODIFIED ADENOSINE KINASE INHIBITORS | GENSIA SICOR INC (US) | 2004-01-14 | — | — | EP | disclosed |
| WO-2003053941-A2 | BARBITURIC ACID DERIVATIVES AS INHIBITORS OF TNF-ALPHA CONVERTING ENZYME (TACE) AND/OR MATRIX METALLOPROTEINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-07-03 | — | — | WO | disclosed |