Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AADAT | Q8N5Z0 | 5/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.33 |
| ▸ | GABRE | P78334 | 1/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.33 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5405752 | 1.00 | AADAT (0.44) | AADATRIPK1L3MBTL1OPRM1OPRK1 | |
| SCHEMBL1562387 | 0.87 | AADAT (0.43) | AADATRIPK1GABRPGABRDGABRA1 | |
| SCHEMBL1562386 | 0.87 | AADAT (0.43) | AADATRIPK1GABRPGABRDGABRA1 | |
| SCHEMBL1561550 | 0.84 | RIPK1 (0.44) | AADATRIPK1GABRPGABRDGABRA1 | |
| SCHEMBL1561549 | 0.84 | RIPK1 (0.44) | AADATRIPK1GABRPGABRDGABRA1 | |
| Hydrochloric Acid SCHEMBL19207975 | 0.83 | RIPK1 (0.43) | AADATRIPK1GABRPGABRDGABRA1 | |
| SCHEMBL1562721 | 0.81 | AADAT (0.40) | AADATRIPK1 | |
| SCHEMBL1562719 | 0.81 | AADAT (0.40) | AADATRIPK1 | |
| SCHEMBL19224570 | 0.81 | RIPK1 (0.46) | AADATRIPK1 | |
| Hydrochloric Acid SCHEMBL28706575 | 0.80 | RIPK1 (0.46) | AADATRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7211573-B2 | Malonamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2007-05-01 | — | — | US | disclosed |
| US-20060122168-A1 | Malonamide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122168-A1 | Malonamide derivatives | ACE, REN, ME1 | AADAT 510/4885RIPK1 3388/4885L3MBTL1 2396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.