SCHEMBL5406345

SCHEMBL5406345

O=Cc1ccc2c(Cl)cccc2c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.50
CYP2A6 P11509 6/20 0.48
CYP1A2 P05177 4/20 0.48
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
TDP1 Q9NUW8 1/20 0.43
KIF11 P52732 2/20 0.41
VCAM1 P19320 1/20 0.41
HSD17B10 Q99714 1/20 0.40
ALDH1A3 P47895 3/20 0.40
CYP3A4 P08684 2/20 0.38
CYP2D6 P10635 2/20 0.38
CYP2C9 P11712 2/20 0.38
CYP2C19 P33261 2/20 0.38
TP53 P04637 1/20 0.38
ALDH3A1 P30838 2/20 0.37
RAB9A P51151 2/20 0.36
NPC1 O15118 1/20 0.36
KDM4E B2RXH2 1/20 0.36
PTGS2 P35354 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4102305 0.85 ALDH1A1 (0.50) ALDH1A1CYP2A6CYP1A2MEN1KMT2A
SCHEMBL216389 0.81 CYP1A2 (0.48) ALDH1A1CYP2A6CYP1A2MEN1KMT2A
SCHEMBL1666511 0.78 KIF11 (0.42) ALDH1A1CYP2A6MEN1KMT2ATDP1
SCHEMBL7841913 0.78 ALDH1A1 (0.47) ALDH1A1CYP2A6CYP1A2KIF11HSD17B10
SCHEMBL28131156 0.78 KIF11 (0.42) ALDH1A1CYP2A6TDP1KIF11HSD17B10
SCHEMBL24215272 0.77 ALDH1A1 (0.55) ALDH1A1CYP2A6KIF11VCAM1HSD17B10
SCHEMBL9670965 0.77 CYP1A2 (0.57) ALDH1A1CYP2A6CYP1A2TDP1KIF11
SCHEMBL9098185 0.77 PLAU (0.53) ALDH1A1CYP1A2TDP1KIF11RAB9A
SCHEMBL4108450 0.77 PTGER4 (0.43) ALDH1A1CYP2A6MEN1KMT2AKIF11
SCHEMBL29951355 0.77 ALDH1A1 (0.48) ALDH1A1CYP2A6CYP1A2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112638891-B Trifluoropyruvyl fluoride dimer and method for producing perfluoro (2, 4-dimethyl-2-fluoro formyl-1, 3-dioxolane) 东曹株式会社 2024-12-10 CN disclosed
WO-2019196714-A1 N-SUBSTITUTED ACRYLAMIDE DERIVATIVE AS DHODH INHIBITOR, AND PREPARATION AND USE THEREOF 华东理工大学 2019-10-17 WO disclosed
US-RE39590-E1 Substituted benzene compounds, process for their preparation, and herbicidal and defoliant compositions containing them ISK AMERICAS INCORPORATED (US) 2007-04-24 US disclosed
CN-1680274-A Substituted benzene compounds, process for their preparation, and herbicidal and defoliant compositions containing them ISK AMERICAS INC (US) 2005-10-12 CN disclosed
CN-1673219-A Substituted benzene compounds, process for their preparation, and herbicidal and defoliant compositions containing them ISK AMERICAS INC (US) 2005-09-28 CN disclosed
US-6545161-B2 Potato and corn crops ISK AMERICAS INCORPORATED 2003-04-08 US disclosed
WO-2002088096-A1 COMPOUNDS INHIBITING CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, PREPARATION AND USES THEREOF NEURO3D (FR) 2002-11-07 WO disclosed
US-6355799-B1 PREEMERGENT HERBICIDE FOR CEREAL CROP FIELDS, DEFOLIANT FOR POTATO AND COTTON PLANTS ISK AMERICAS INCORPORATED 2002-03-12 US disclosed