Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.40 |
| ▸ | TAS1R2 | Q8TE23 | 4/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13499150 | 0.84 | ALDH1A1 (0.39) | BDKRB1ALDH1A1LMNAHSD17B10TAS1R3 | |
| SCHEMBL3536911 | 0.81 | LMNA (0.49) | BDKRB1ALDH1A1HTTLMNAHSD17B10 | |
| SCHEMBL3532546 | 0.80 | CFD (0.56) | BDKRB1ALDH1A1HTTLMNAHSD17B10 | |
| SCHEMBL5321544 | 0.79 | BDKRB1 (0.46) | BDKRB1ALDH1A1HTTLMNAHSD17B10 | |
| SCHEMBL13936479 | 0.76 | ESR1 (0.39) | — | |
| SCHEMBL5183278 | 0.75 | BDKRB1 (0.68) | BDKRB1 | |
| SCHEMBL5277198 | 0.75 | BDKRB1 (0.59) | BDKRB1 | |
| SCHEMBL22772302 | 0.74 | TAS1R3 (0.55) | ALDH1A1HTTLMNATAS1R3TAS1R1 | |
| SCHEMBL4524080 | 0.74 | ALDH1A1 (0.38) | BDKRB1ALDH1A1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL4524083 | 0.74 | ALDH1A1 (0.38) | BDKRB1ALDH1A1TAS1R3TAS1R1TAS1R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856074-A2 | SUBSTITUTED ARYL OR HETEROARYLSULFONYLBUTANAMIDES FOR USE AS ANTI-INFLAMMATORY AGENTS | Amgen, Inc (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006041888-A2 | SUBSTITUTED ARYL OR HETEROARYLSULFONYLBUTANAMIDES FOR USE AS ANTI-INFLAMMATORY AGENTS | AMGEN INC. (US) | 2006-04-20 | — | — | WO | disclosed |