Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | TYMS | P04818 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6708105 | 0.81 | ALDH1A1 (0.43) | POLBKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL5229303 | 0.80 | KDM4E (0.40) | POLBKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL3295735 | 0.77 | ALDH1A1 (0.37) | POLBKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL4495841 | 0.75 | MAPK10 (0.42) | POLBKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL29588824 | 0.75 | MAPK10 (0.42) | POLBKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL118020 | 0.71 | MAOA (0.40) | POLBKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL9311258 | 0.70 | GAA (0.40) | POLBKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL4501863 | 0.68 | CDK4 (0.44) | POLBKMT2AMEN1ALDH1A1MAPT | |
| Cinnamic Acid SCHEMBL5929391 | 0.68 | HCAR2 (0.39) | POLBKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL4892024 | 0.68 | CDK4 (0.41) | POLBKMT2AMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7276512-B2 | Benzo[a]pyrano[3,2-h]acridin-7-one compounds | LES LABORATOIRES SERVIER (FR) | 2007-10-02 | — | — | US | disclosed |
| CN-1289502-C | New derivatives of benzo[a]pyrano[3,2-h]acridin-7-one, a process for their preparation and pharmaceutical compounds containing them | SERVIER LAB (FR) | 2006-12-13 | — | — | CN | disclosed |
| CN-1576277-A | New derivatives of benzo[a]pyrano[3,2-h]acridin-7-one, a process for their preparation and pharmaceutical compounds containing them | SERVIER LAB (FR) | 2005-02-09 | — | — | CN | disclosed |
| US-20040266753-A1 | Benzo[a]pyrano[3,2-h]acridin-7-one compounds | LES LABORATOIRES SERVIER (FR) | 2004-12-30 | — | — | US | disclosed |
| EP-1491544-A1 | Benzo[a]pyrano[3,2-h]acridin-7-one derivatives, processes for their preparation and pharmaceutical compositions thereof | Les Laboratoires Servier (FR) | 2004-12-29 | — | — | EP | disclosed |
| EP-1491544-A1 | Benzo[a]pyrano[3,2-h]acridin-7-one derivatives, processes for their preparation and pharmaceutical compositions thereof | Les Laboratoires Servier (FR) | 2004-12-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266753-A1 | Benzo[a]pyrano[3,2-h]acridin-7-one compounds | CBR1, AHR, AR | POLB 849/4885PTPN1 642/4885TYMS 1357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.