Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 2/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.48 |
| ▸ | STS | P08842 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.45 |
| ▸ | GLS | O94925 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4402076 | 0.85 | GPR119 (0.45) | YAP1GPR119STSACHEKDM4E | |
| SCHEMBL16868764 | 0.85 | MAPT (0.57) | YAP1POLBMEN1KMT2A | |
| SCHEMBL18481442 | 0.83 | KDM1A (0.47) | YAP1STSCYP3A4MEN1KMT2A | |
| SCHEMBL12512936 | 0.81 | ALDH1A1 (0.45) | KDM4EMEN1KMT2A | |
| SCHEMBL31189365 | 0.80 | CTSB (0.43) | YAP1GPR119STSACHEP2RX7 | |
| SCHEMBL5413838 | 0.80 | GPR119 (0.47) | YAP1GPR119STSACHEKDM4E | |
| SCHEMBL1683002 | 0.79 | RAB9A (0.58) | CYP3A4CYP2D6CYP2C9CYP2C19POLB | |
| SCHEMBL14244893 | 0.79 | SYK (0.53) | YAP1GPR119CYP2C19P2RX7MEN1 | |
| SCHEMBL27853832 | 0.79 | SYK (0.53) | YAP1GPR119CYP2C19P2RX7MEN1 | |
| SCHEMBL5083759 | 0.79 | ALDH1A1 (0.61) | GPR119KDM4EPKMCYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169777-B2 | Melanocortin receptor agonists | ELI LILLY AND COMPANY (US) | 2007-01-30 | — | — | US | disclosed |
| US-20040116699-A1 | Melanocortin receptor agonists | ELI LILLY AND COMPANY | 2004-06-17 | — | — | US | disclosed |
| EP-1358163-A1 | MELANOCORTIN RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002059095-A1 | MELANOCORTIN RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2002-08-01 | — | — | WO | disclosed |