Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.46 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.46 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.46 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 3/20 | 0.45 |
| ▸ | TACR1 | P25103 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15254319 | 1.00 | CASP1 (0.50) | CASP1ALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL8765287 | 0.92 | CASP1 (0.57) | CASP1ALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL8765277 | 0.92 | CASP1 (0.57) | CASP1ALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL15272012 | 0.90 | CASP1 (0.48) | CASP1ALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL5405717 | 0.87 | CASP1 (0.52) | CASP1ALDH1A1CTSKTACR1IDO1 | |
| SCHEMBL14102872 | 0.85 | FOLH1 (0.54) | CASP1ALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL14102865 | 0.85 | FOLH1 (0.54) | CASP1ALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL14102857 | 0.85 | FOLH1 (0.54) | CASP1ALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL21805219 | 0.85 | ALDH1A1 (0.48) | CASP1ALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL21805220 | 0.85 | ALDH1A1 (0.48) | CASP1ALDH1A1MEN1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2825528-B1 | SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES | HOFFMANN LA ROCHE (CH) | 2017-05-24 | — | — | EP | disclosed |
| US-8993614-B2 | Substituted pyrrolidine-2-carboxamides | F. HOFFMANN-LA ROCHE AG (CH) | 2015-03-31 | — | — | US | disclosed |
| EP-2825528-A1 | SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES | F. Hoffmann-La Roche AG (CH) | 2015-01-21 | — | — | EP | disclosed |
| WO-2013135648-A1 | SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2013-09-19 | — | — | WO | disclosed |
| US-20130244958-A1 | SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES | HOFFMANN-LA ROCHE INC. (US) | 2013-09-19 | — | — | US | disclosed |
| US-7169803-B2 | N-substituted prodrugs of fluorooxindoles | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-01-30 | — | — | US | disclosed |
| US-20050203089-A1 | N-substituted prodrugs of fluorooxindoles | BRISTOL-MYERS SQUIBB COMPANY | 2005-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203089-A1 | N-substituted prodrugs of fluorooxindoles | KCNA5, KCNQ5, KCNQ2 | CASP1 1558/4885ALDH1A1 2272/4885MEN1 1213/4885 |
| US-20130244958-A1 | SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES | CCNY, ARG2, RPS4Y1 | CASP1 737/4885ALDH1A1 1924/4885MEN1 2576/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.