SCHEMBL540885

SCHEMBL540885

O=[N+]([O-])c1ncccc1CCl

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.52
TSHR P16473 2/20 0.52
NPC1 O15118 3/20 0.44
RAB9A P51151 3/20 0.44
S1PR4 O95977 1/20 0.44
KMT2A Q03164 3/20 0.43
MEN1 O00255 1/20 0.43
POLB P06746 3/20 0.41
MAPT P10636 3/20 0.41
KDM4E B2RXH2 1/20 0.41
RECQL P46063 1/20 0.41
MCL1 Q07820 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
PDE10A Q9Y233 1/20 0.40
HTT P42858 1/20 0.39
ESR2 Q92731 1/20 0.39
CYP1A2 P05177 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C9 P11712 1/20 0.38
CASP1 P29466 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8529530 0.81 KMT2A (0.43) ALDH1A1TSHRNPC1RAB9AS1PR4
SCHEMBL5117671 0.81 ALDH1A1 (0.44) ALDH1A1TSHRNPC1RAB9AS1PR4
SCHEMBL2125795 0.81 KMT2A (0.43) ALDH1A1TSHRNPC1RAB9AS1PR4
SCHEMBL4666888 0.81 NPC1 (0.48) ALDH1A1NPC1RAB9AS1PR4KMT2A
SCHEMBL10563192 0.80 KMT2A (0.60) ALDH1A1TSHRNPC1RAB9AS1PR4
SCHEMBL29903448 0.79 KMT2A (0.41) ALDH1A1TSHRNPC1RAB9AS1PR4
SCHEMBL3167072 0.79 KMT2A (0.41) ALDH1A1TSHRNPC1RAB9AS1PR4
SCHEMBL27873051 0.79 KMT2A (0.41) ALDH1A1TSHRNPC1RAB9AS1PR4
SCHEMBL8601536 0.77 PDE4A (0.41) ALDH1A1NPC1RAB9AS1PR4KMT2A
SCHEMBL7116983 0.77 KMT2A (0.50) ALDH1A1NPC1RAB9AKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-3937831-A CHLOROMETHYL NITROPYRIDINES AS ANTIMICROBIALS THE DOW CHEMICAL COMPANY (US) 1976-02-10 US claimed
EP-2438063-A1 1H-IMIDAZO[4,5-C]QUINOLINONE COMPOUNDS, USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES Novartis AG (CH) 2012-04-11 EP disclosed
EP-2413693-A1 SUBSTITUTED AZOANTHRACENE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF TransTech Pharma, Inc (US) 2012-02-08 EP disclosed
WO-2010139747-A1 1H-IMIDAZO[4, 5-c]QUINOLINONE COMPOUNDS, USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES NOVARTIS AG (CH) 2010-12-09 WO disclosed
WO-2010114824-A1 SUBSTITUTED AZOANTHRACENE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF TRANSTECH PHARMA INC (US) 2010-10-07 WO disclosed
EP-0735025-B1 Process for producing aminonitropyridines SUMITOMO CHEMICAL CO (JP) 1998-07-01 EP disclosed
US-5648496-A AMINATION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-07-15 US disclosed
EP-0735025-A1 Process for producing aminonitropyridines SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1996-10-02 EP disclosed
US-3937831-A CHLOROMETHYL NITROPYRIDINES AS ANTIMICROBIALS THE DOW CHEMICAL COMPANY (US) 1976-02-10 US disclosed
US-3937831-A CHLOROMETHYL NITROPYRIDINES AS ANTIMICROBIALS THE DOW CHEMICAL COMPANY (US) 1976-02-10 US disclosed