Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.35 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL5409741 | 0.83 | MEN1 (0.38) | MEN1KMT2AALDH1A1CYP1A2THRB | |
| Proline SCHEMBL140698 | 0.77 | TLR2 (0.34) | MEN1KMT2ACYP1A2CYP2C19 | |
| Proline SCHEMBL3519298 | 0.72 | TLR2 (0.32) | — | |
| Proline SCHEMBL442338 | 0.72 | ACE (0.40) | MEN1KMT2AALDH1A1CYP1A2THRB | |
| SCHEMBL2043828 | 0.72 | NOS2 (0.37) | MEN1KMT2ACYP1A2CYP2C19 | |
| Proline SCHEMBL7937459 | 0.72 | MEN1 (0.49) | MEN1KMT2AALDH1A1CYP1A2THRB | |
| Proline SCHEMBL7937455 | 0.72 | MEN1 (0.49) | MEN1KMT2AALDH1A1CYP1A2THRB | |
| SCHEMBL24587253 | 0.71 | TLR2 (0.40) | CYP1A2CYP2C19 | |
| SCHEMBL27114716 | 0.71 | TLR2 (0.40) | CYP1A2CYP2C19 | |
| SCHEMBL10363588 | 0.70 | RAB9A (0.39) | CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259022-B2 | Production of motif-specific and context-independent antibodies using peptide libraries as antigens | CELL SIGNALING TECHNOLOGY, INC. (US) | 2007-08-21 | — | — | US | claimed |
| US-20020168684-A1 | Production of motif-specific and context-independent antibodies using peptide libraries as antigens | CELL SIGNALING TECHNOLOGY, INC. | 2002-11-14 | — | — | US | claimed |
| US-20230033264-A1 | MOTIF-SPECIFIC AND CONTEXT-INDEPENDENT ANTIBODIES THAT SPECIFICALLY BIND TO A SUMOYLATED LYSINE-CONTAINING RESIDUE | CELL SIGNALING TECHNOLOGY, INC. (US) | 2023-02-02 | — | — | US | disclosed |
| US-11377486-B2 | Motif-specific and context-independent antibodies that specifically bind to a sumoylated lysine-containing residue | CELL SIGNALING TECHNOLOGY, INC. (US) | 2022-07-05 | — | — | US | disclosed |
| US-11352418-B2 | Analysis of ubiquitinated polypeptides | CELL SIGNALING TECHNOLOGY, INC. (US) | 2022-06-07 | — | — | US | disclosed |
| US-20200317760-A1 | Motif-Specific and Context-Independent Antibodies That Specifically Bind to a Sumoylated Lysine-Containing Residue | CELL SIGNALING TECHNOLOGY, INC. | 2020-10-08 | — | — | US | disclosed |
| US-20200131254-A1 | Analysis of Ubiquitinated Polypeptides | CELL SIGNALING TECHNOLOGY, INC. | 2020-04-30 | — | — | US | disclosed |
| US-20180009884-A1 | Production of Motif-Specific and Context-Independent Antibodies Using Peptide Libraries as Antigens | CELL SIGNALING TECHNOLOGY, INC. | 2018-01-11 | — | — | US | disclosed |
| US-9738711-B2 | Production of motif-specific and context-independent antibodies using peptide libraries as antigens | CELL SIGNALING TECHNOLOGY, INC. (US) | 2017-08-22 | — | — | US | disclosed |
| US-20160319001-A1 | Motif-Specific and Context-Independent Antibodies That Specifically Bind to a Cleaved Caspase Motif | CELL SIGNALING TECHNOLOGY, INC. | 2016-11-03 | — | — | US | disclosed |
| US-9249231-B2 | Motif-specific and context-independent antibodies that specifically bind to a cleaved caspase motif | CELL SIGNALING TECHNOLOGY, INC. (US) | 2016-02-02 | — | — | US | disclosed |
| US-20150259405-A1 | Production of Motif-Specific and Context-Independent Antibodies Using Peptide Libraries as Antigens | CELL SIGNALING TECHNOLOGY, INC. | 2015-09-17 | — | — | US | disclosed |
| US-20150232540-A1 | ANALYSIS OF UBIQUITNATED POLYPEPTIDES | CELL SIGNALING TECHNOLOGY INC (US) | 2015-08-20 | — | — | US | disclosed |
| US-9085609-B2 | Production of motif-specific and context-independent antibodies using peptide libraries as antigens | CELL SIGNALING TECHNOLOGY, INC. (US) | 2015-07-21 | — | — | US | disclosed |
| US-20120208985-A1 | Motif-Specific and Context-Independent Antibodies That Specifically Bind to a Cleaved Caspase Motif or a Sumoylated Lysine-Containing Motif | CELL SIGNALING TECHNOLOGY, INC. (US) | 2012-08-16 | — | — | US | disclosed |
| US-7259022-B2 | Production of motif-specific and context-independent antibodies using peptide libraries as antigens | CELL SIGNALING TECHNOLOGY, INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-20070026461-A1 | Production of motif-specific and context-independent antibodies using peptide libraries as antigens | CELL SIGNALING TECHNOLOGY, INC. | 2007-02-01 | — | — | US | disclosed |
| US-20020168684-A1 | Production of motif-specific and context-independent antibodies using peptide libraries as antigens | CELL SIGNALING TECHNOLOGY, INC. | 2002-11-14 | — | — | US | disclosed |