Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.57 |
| ▸ | ADRA1D known ✓ | P25100 | 2/20 | 0.54 |
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.54 |
| ▸ | ADRA1B known ✓ | P35368 | 2/20 | 0.54 |
| ▸ | DRD2 | P14416 | 6/20 | 0.58 |
| ▸ | DRD3 | P35462 | 4/20 | 0.58 |
| ▸ | HTR1A | P08908 | 6/20 | 0.57 |
| ▸ | HTR7 | P34969 | 3/20 | 0.57 |
| ▸ | HTR6 | P50406 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4528941 | 0.93 | DRD2 (0.64) | DRD2DRD3HTR1AHTR7HTR2A | |
| Hydrochloric Acid SCHEMBL4520908 | 0.92 | DRD2 (0.63) | DRD2DRD3HTR1AHTR7HTR2A | |
| Succinic Acid SCHEMBL5330215 | 0.91 | DRD2 (0.60) | DRD2DRD3HTR1AHTR7HTR2A | |
| Maleic Acid SCHEMBL5428000 | 0.90 | DRD2 (0.59) | DRD2DRD3HTR1AHTR7HTR2A | |
| Fumaric Acid SCHEMBL5410380 | 0.90 | DRD2 (0.59) | DRD2DRD3HTR1AHTR7HTR2A | |
| Cadaverine Tartrate SCHEMBL5327025 | 0.90 | HTR1A (0.46) | DRD2DRD3HTR1AHTR7HTR2A | |
| Phosphoric Acid SCHEMBL5422467 | 0.89 | HTR1A (0.63) | DRD2DRD3HTR1AHTR7HTR2A | |
| SCHEMBL6211445 | 0.85 | DRD2 (0.52) | DRD2DRD3HTR1AHTR7HTR2A | |
| Hydrochloric Acid SCHEMBL6214323 | 0.84 | DRD2 (0.51) | DRD2DRD3HTR1AHTR7HTR2A | |
| SCHEMBL5176069 | 0.84 | HTR1A (0.55) | DRD2DRD3HTR1AHTR7HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007010504-A2 | ACID ADDITION SALTS OF ISOINDOLES ACTING AS ADRENERGIC RECEPTOR ANTAGONISTS | RANBAXY LABORATORIES LIMITED (IN) | 2007-01-25 | — | — | WO | disclosed |