Phosphoric Acid

Phosphoric Acid

SCHEMBL5422467

COc1ccccc1N1CCN(CCCN2C(=O)C3CCC(O)CC3C2=O)CC1.O=P(O)(O)O

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA1D known ✓ P25100 2/20 0.57
ADRA1A known ✓ P35348 2/20 0.57
ADRA1B known ✓ P35368 2/20 0.57
HTR1A P08908 6/20 0.63
DRD2 P14416 5/20 0.63
HTR7 P34969 3/20 0.63
HTR2A P28223 1/20 0.63
HTR6 P50406 1/20 0.63
DRD3 P35462 4/20 0.59
ALDH1A1 P00352 2/20 0.57
MEN1 O00255 2/20 0.57
KMT2A Q03164 2/20 0.57
CYP3A4 P08684 1/20 0.57
CYP2D6 P10635 1/20 0.57
ALOX12 P18054 1/20 0.57
HIF1A Q16665 1/20 0.57
HSD17B10 Q99714 1/20 0.57
KDM4E B2RXH2 1/20 0.56
GLA P06280 1/20 0.56
HPGD P15428 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4528941 0.96 DRD2 (0.64) HTR1ADRD2HTR7HTR2AHTR6
Hydrochloric Acid SCHEMBL4520908 0.95 DRD2 (0.63) HTR1ADRD2HTR7HTR2AHTR6
Succinic Acid SCHEMBL5330215 0.91 DRD2 (0.60) HTR1ADRD2HTR7HTR2AHTR6
Maleic Acid SCHEMBL5428000 0.90 DRD2 (0.59) HTR1ADRD2HTR7HTR2AHTR6
Fumaric Acid SCHEMBL5410380 0.90 DRD2 (0.59) HTR1ADRD2HTR7HTR2AHTR6
Cadaverine Tartrate SCHEMBL5410107 0.89 DRD2 (0.58) HTR1ADRD2HTR7HTR2AHTR6
Phosphoric Acid SCHEMBL5327365 0.89 HTR1A (0.49) HTR1ADRD2HTR7HTR2AHTR6
SCHEMBL5422475 0.87 DRD2 (0.61) HTR1ADRD2HTR7HTR2AHTR6
SCHEMBL5176069 0.87 HTR1A (0.55) HTR1ADRD2HTR7HTR2AHTR6
Hydrochloric Acid SCHEMBL6407537 0.86 HTR1A (0.55) HTR1ADRD2HTR7HTR2AHTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007010504-A2 ACID ADDITION SALTS OF ISOINDOLES ACTING AS ADRENERGIC RECEPTOR ANTAGONISTS RANBAXY LABORATORIES LIMITED (IN) 2007-01-25 WO disclosed