Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.73 |
| ▸ | MEN1 | O00255 | 3/20 | 0.73 |
| ▸ | TP53 | P04637 | 2/20 | 0.73 |
| ▸ | MAPT | P10636 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.65 |
| ▸ | EGFR | P00533 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | TGM2 | P21980 | 1/20 | 0.59 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12857883 | 0.85 | KMT2A (0.74) | KMT2AMEN1TP53MAPTALDH1A1 | |
| SCHEMBL10144823 | 0.79 | KDM4E (0.69) | KMT2AMEN1TP53MAPTALDH1A1 | |
| SCHEMBL3913381 | 0.78 | ALDH1A1 (0.71) | KMT2AMEN1TP53MAPTALDH1A1 | |
| SCHEMBL9972172 | 0.78 | MAPT (0.76) | KMT2AMEN1TP53MAPTALDH1A1 | |
| SCHEMBL13407750 | 0.78 | MAPT (0.75) | KMT2AMEN1TP53MAPTALDH1A1 | |
| SCHEMBL9972173 | 0.76 | MAPT (0.72) | KMT2AMEN1TP53MAPTALDH1A1 | |
| SCHEMBL19079839 | 0.74 | KDM4E (0.73) | KMT2AMEN1TP53MAPTALDH1A1 | |
| SCHEMBL20228786 | 0.74 | KMT2A (1.00) | KMT2AMEN1TP53MAPTALDH1A1 | |
| SCHEMBL6037625 | 0.74 | TGM2 (1.00) | KMT2AMEN1ALDH1A1KDM4EHTT | |
| SCHEMBL20228784 | 0.73 | KMT2A (0.85) | KMT2AMEN1TP53MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413696-A1 | COMPOSITIONS FOR TREATMENT OF ALZHEIMER'S DISEASE | Mount Sinai School Of Medicine Of New York University (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114636-A1 | COMPOSITIONS FOR TREATMENT OF ALZHEIMER'S DISEASE | MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY (US) | 2010-10-07 | — | — | WO | disclosed |