Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 6/20 | 0.47 |
| ▸ | PDE1B | Q01064 | 6/20 | 0.47 |
| ▸ | PDE1C | Q14123 | 6/20 | 0.47 |
| ▸ | PDE2A | O00408 | 5/20 | 0.43 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | PDE5A | O76074 | 2/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
| ▸ | PDE6C | P51160 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3084224 | 0.81 | PDE1A (0.52) | PDE1APDE1BPDE1CPDE2ASLC16A1 | |
| SCHEMBL7000713 | 0.79 | MAPT (0.47) | PDE1APDE1BPDE1CPDE2AADORA1 | |
| SCHEMBL5419584 | 0.78 | SLC16A1 (0.67) | PDE1APDE1BPDE1CSLC16A1PDE5A | |
| Isobutyraldehyde SCHEMBL3661931 | 0.77 | PDE1A (0.48) | PDE1APDE1BPDE1CPDE2ASLC16A1 | |
| SCHEMBL7446470 | 0.77 | PDE1B (0.46) | PDE1APDE1BPDE1CPDE2ASLC16A1 | |
| Butanone SCHEMBL3661929 | 0.75 | PDE1A (0.46) | PDE1APDE1BPDE1CPDE2ASLC16A1 | |
| SCHEMBL11181039 | 0.75 | PDE1A (0.47) | PDE1APDE1BPDE1CPDE2ASLC16A1 | |
| SCHEMBL11184207 | 0.73 | PDE1A (0.45) | PDE1APDE1BPDE1CPDE2ASLC16A1 | |
| SCHEMBL5407840 | 0.71 | KDM4E (0.41) | PDE1APDE1BPDE1CPDE2ASLC16A1 | |
| SCHEMBL18330288 | 0.70 | ALDH1A1 (0.54) | ADORA3MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7285558-B2 | Pyrazolo[3,4-d]pyrimidines inhibiting H. pylori infections | ASTRAZENECA AB (SE) | 2007-10-23 | — | — | US | disclosed |
| US-20040254183-A1 | Pyrazolo[3,4-d]pyrimidines inhibiting h. pylori infections | ASTRAZENECA AB (SE) | 2004-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254183-A1 | Pyrazolo[3,4-d]pyrimidines inhibiting h. pylori infections | DPYD, HPGDS, PGC | PDE1A 4056/4885PDE1B 4206/4885PDE1C 4660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.