Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 17/20 | 0.63 |
| ▸ | PPARG | P37231 | 13/20 | 0.63 |
| ▸ | PPARD | Q03181 | 2/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tert-Butylamine SCHEMBL3112027 | 0.94 | PPARA (0.68) | PPARAPPARGPPARDFFAR1 | |
| SCHEMBL3100619 | 0.93 | PPARA (0.71) | PPARAPPARGPPARDFFAR1 | |
| SCHEMBL3946198 | 0.93 | PPARA (0.71) | PPARAPPARGPPARDFFAR1 | |
| SCHEMBL3100628 | 0.93 | PPARA (0.71) | PPARAPPARGPPARDFFAR1 | |
| SCHEMBL5474463 | 0.92 | PPARA (0.70) | PPARAPPARGPPARDFFAR1 | |
| Piperazine SCHEMBL5413975 | 0.87 | PPARA (0.65) | PPARAPPARGPPARDFFAR1 | |
| SCHEMBL5689292 | 0.86 | PPARA (0.63) | PPARAPPARGPPARDFFAR1 | |
| SCHEMBL5411528 | 0.86 | PPARA (0.61) | PPARAPPARGPPARDFFAR1 | |
| SCHEMBL5692564 | 0.85 | PPARA (0.69) | PPARAPPARGPPARDFFAR1 | |
| SCHEMBL13156113 | 0.85 | PPARA (0.60) | PPARAPPARGPPARDFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070099928-A1 | Amine salts of (-)-2-{2-(4-hydroxyphenyl) ethyl]thio} -3-4-(2-{4-(methylsulfonyl) oxy phenyl propanoic acid and their use in medicine | ASTRAZENECA (SE) | 2007-05-03 | — | — | US | disclosed |
| EP-1638930-A1 | AMINE SALTS OF (-)-2- ¬2-(4-HYDROXYPHENYL)ETHYL|-THIO -3-¬4-(2- 4-¬(METHYLSULFONYL)OXY|PHENOXY ETHYL)PHENYL|PROPANOIC ACID AND THEIR USE IN MEDICINE. | Astrazeneca AB (SE) | 2006-03-29 | — | — | EP | disclosed |
| WO-2004113283-A1 | AMINE SALTS OF (-)-2-{`2-(4-HYDROXYPHENYL) ETHYL!-THIO}-3-`4-(2-{4-`(METHYLSULFONYL)OXY! PHENOXY}ETHYL)PHENYL! PROPANOIC ACID AND THERE USE IN MEDICINE | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099928-A1 | Amine salts of (-)-2-{2-(4-hydroxyphenyl) ethyl]thio} -3-4-(2-{4-(methylsulfonyl) oxy phenyl propanoic acid and their use in medicine | EP300, LIPC, CPT1A | PPARA 131/4885PPARG 481/4885PPARD 458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.