Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 16/20 | 0.71 |
| ▸ | PPARG | P37231 | 12/20 | 0.71 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3946198 | 1.00 | PPARA (0.71) | PPARAPPARGFFAR1PPARD | |
| SCHEMBL3100619 | 1.00 | PPARA (0.71) | PPARAPPARGFFAR1PPARD | |
| SCHEMBL5474463 | 0.99 | PPARA (0.70) | PPARAPPARGFFAR1PPARD | |
| Tert-Butylamine SCHEMBL3112027 | 0.95 | PPARA (0.68) | PPARAPPARGFFAR1PPARD | |
| Piperazine SCHEMBL5413975 | 0.94 | PPARA (0.65) | PPARAPPARGFFAR1PPARD | |
| SCHEMBL5689292 | 0.93 | PPARA (0.63) | PPARAPPARGFFAR1PPARD | |
| Tromethamine SCHEMBL5411518 | 0.93 | PPARA (0.63) | PPARAPPARGFFAR1PPARD | |
| SCHEMBL5692564 | 0.92 | PPARA (0.69) | PPARAPPARGFFAR1PPARD | |
| SCHEMBL3946462 | 0.92 | PPARA (0.84) | PPARAPPARGFFAR1PPARD | |
| SCHEMBL5526960 | 0.92 | PPARA (0.84) | PPARAPPARGFFAR1PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458677-B1 | 3-PHENYL-2-ARYLALKYLTHIOPROPIONIC ACID DERIVATIVES AS SELECTIVE AGONISTS OF PPAR-ALPHA | ASTRAZENECA AB (SE) | 2009-04-15 | — | — | EP | claimed |
| US-7429675-B2 | Process for the preparation of racemic 2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4-(2-{4-[(methylsulfonyl)oxy]phenoxy}ethyl)phenyl]-propanoic acid | ASTRAZENECA AB (SE) | 2008-09-30 | — | — | US | claimed |
| US-20080090905-A1 | Amine Salts Of (-)-2-((2-(4-Hydroxyphenyl)Ethyl)Thio)-3-(4-(2-(4-((Methylsulfonyl)Oxy)Phenoxy)Ethyl)Phenyl) Propanoic Acid | SNAPE EVAN W | 2008-04-17 | — | — | US | claimed |
| US-7276539-B2 | 3-Phenyl-2-arylalkylthiopropionic acid derivatives as selective agonists of ppar-alpha | ASTRAZENECA AB (SE) | 2007-10-02 | — | — | US | claimed |
| EP-1828112-A1 | AMINE SALTS OF (-)-2-((2-(4-HYDROXYPHENYL)ETHYL)THIO)-3-(4-(2-(4-((METHYLSULFONYL)OXY)PHENOXY)ETHYL)PHENYL)PROPANOIC ACID | AstraZeneca AB (SE) | 2007-09-05 | — | — | EP | claimed |
| US-20070099928-A1 | Amine salts of (-)-2-{2-(4-hydroxyphenyl) ethyl]thio} -3-4-(2-{4-(methylsulfonyl) oxy phenyl propanoic acid and their use in medicine | ASTRAZENECA (SE) | 2007-05-03 | — | — | US | claimed |
| US-20060167309-A1 | Process for the preparation of racemic 2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4-(2-{4-[(methylsulfonyl)oxy]phenoxy}ethyl)pheyl]-propanoic acid | ASTRAZENECA AB (SE) | 2006-07-27 | — | — | US | claimed |
| WO-2006064232-A1 | AMINE SALTS OF (-)-2-((2-(4-HYDROXYPHENYL)ETHYL)THIO)-3-(4-(2-(4-((METHYLSULFONYL)OXY) PHENOXY)ETHYL)PHENYL) PROPANOIC ACID | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | claimed |
| EP-1641749-A1 | POTASSIUM OR SODIUM SALT OF (-)-2- {'2-(4-HYDROXYPHENYL)ETHYL]-THIO -3-'4-(2- {4-'(METHYLSULFONYL)OXY ]PHENOXY }PHENYL]PROPANOIC ACID AND THEIR USE IN MEDICINE. | Astrazeneca AB (SE) | 2006-04-05 | — | — | EP | claimed |
| EP-1638930-A1 | AMINE SALTS OF (-)-2- ¬2-(4-HYDROXYPHENYL)ETHYL|-THIO -3-¬4-(2- 4-¬(METHYLSULFONYL)OXY|PHENOXY ETHYL)PHENYL|PROPANOIC ACID AND THEIR USE IN MEDICINE. | Astrazeneca AB (SE) | 2006-03-29 | — | — | EP | claimed |
| EP-1638929-A1 | PROCESS FOR THE PREPARATION OF RACEMIC 2- ¬2-(4-HYDROXYPHENYL)ETHYL|-THIO -3-¬4-(2- 4-¬(METHYLSULFONYL)OXY|PHENOXY ETHYL)PHENYL|PROPANOIC ACID. | Astrazeneca AB (SE) | 2006-03-29 | — | — | EP | claimed |
| US-20050215630-A1 | 3-Phenyl-2-arylalkylthiopropionic acid derivatives as selective agonists of ppar-alpha | ASTRAZENECA AB (SE) | 2005-09-29 | — | — | US | claimed |
| WO-2004113285-A1 | PROCESS FOR THE PREPARATION OF RACEMIC 2-{[2-(4-HYDROXYPHENYL)ETHYL]THIO}-3-[4-(2-{4-[(METHYLSULFONYL)OXY]PHENOXY}ETHYL)PHENYL]-PROPANOIC ACID | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | WO | claimed |
| WO-2004113283-A1 | AMINE SALTS OF (-)-2-{`2-(4-HYDROXYPHENYL) ETHYL!-THIO}-3-`4-(2-{4-`(METHYLSULFONYL)OXY! PHENOXY}ETHYL)PHENYL! PROPANOIC ACID AND THERE USE IN MEDICINE | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | WO | claimed |
| WO-2004113284-A1 | POTASSIUM OR SODIUM SALT OF (-)-2-{`2-(4-HYDROXYPHENYL)ETHYL!-THIO-3-`4-(2-{4-`(METHZLSULFONZL) OXY !PHENOXY}PHENYL!PROPANOIC ACID AND THEIR USE IN MEDICINE | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | WO | claimed |
| EP-1458677-A1 | 3-PHENYL-2-ARYLALKYLTHIOPROPIONIC ACID DERIVATIVES AS SELECTIVE AGONISTS OF PPAR-ALPHA | Astrazeneca AB (SE) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051826-A1 | 3-PHENYL-2-ARYLALKYLTHIOPROPIONIC ACID DERIVATIVES AS SELECTIVE AGONISTS OF PPAR-ALPHA | ASTRAZENECA AB (SE) | 2003-06-26 | — | — | WO | claimed |
| US-7803586-B2 | Chemical Process | ASTRAZENECA AB (SE) | 2010-09-28 | — | — | US | disclosed |
| EP-1458677-A1 | 3-PHENYL-2-ARYLALKYLTHIOPROPIONIC ACID DERIVATIVES AS SELECTIVE AGONISTS OF PPAR-ALPHA | Astrazeneca AB (SE) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003051826-A1 | 3-PHENYL-2-ARYLALKYLTHIOPROPIONIC ACID DERIVATIVES AS SELECTIVE AGONISTS OF PPAR-ALPHA | ASTRAZENECA AB (SE) | 2003-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099928-A1 | Amine salts of (-)-2-{2-(4-hydroxyphenyl) ethyl]thio} -3-4-(2-{4-(methylsulfonyl) oxy phenyl propanoic acid and their use in medicine | EP300, LIPC, CPT1A | PPARA 131/4885PPARG 481/4885FFAR1 212/4885 |
| US-20080090905-A1 | Amine Salts Of (-)-2-((2-(4-Hydroxyphenyl)Ethyl)Thio)-3-(4-(2-(4-((Methylsulfonyl)Oxy)Phenoxy)Ethyl)Phenyl) Propanoic Acid | GPR119, CPT1B, PNLIP | PPARA 75/4885PPARG 554/4885FFAR1 97/4885 |
| US-20050215630-A1 | 3-Phenyl-2-arylalkylthiopropionic acid derivatives as selective agonists of ppar-alpha | PPARA, PPARG, PPARD | PPARA 1/4885PPARG 2/4885FFAR1 5/4885 |
| US-20060167309-A1 | Process for the preparation of racemic 2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4-(2-{4-[(methylsulfonyl)oxy]phenoxy}ethyl)pheyl]-propanoic acid | HPD, PAH, HAAO | PPARA 446/4885PPARG 1596/4885FFAR1 309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.