Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL541415 | 0.89 | TDP1 (0.46) | MAPK1HTTTP53SMN1; SMN2ALOX15 | |
| SCHEMBL3732608 | 0.82 | MAPK1 (0.59) | MAPK1HTTKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL541624 | 0.80 | TP53 (0.40) | TP53KDM4ELMNASMN1; SMN2HSD17B10 | |
| SCHEMBL8396869 | 0.75 | RECQL (0.60) | MAPK1HTTKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL7762886 | 0.74 | HSD17B10 (0.72) | MAPK1HTTKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL3667518 | 0.73 | HSD17B10 (0.72) | MAPK1HTTKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL9262862 | 0.73 | ALOX15 (0.58) | MAPK1HTTTP53SMN1; SMN2HSD17B10 | |
| SCHEMBL7257420 | 0.73 | MAPT (0.60) | TP53KDM4ELMNASMN1; SMN2GAA | |
| SCHEMBL7254234 | 0.71 | AGTR1 (0.62) | HTTTP53LMNASMN1; SMN2MAPT | |
| SCHEMBL7260911 | 0.70 | TP53 (0.61) | TP53SMN1; SMN2MAPTAGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044033-B1 | A REGIOSELECTIVE PALLADIUM CATALYZED SYNTHESIS OF BENZIMIDAZOLES AND AZABENZIMIDAZOLES | SANOFI SA (FR) | 2012-02-08 | — | — | EP | claimed |