Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.37 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5415360 | 0.93 | HDAC6 (0.44) | HDAC6HDAC8HDAC2HDAC1PAX8 | |
| Trifluoroacetic Acid SCHEMBL5420943 | 0.92 | HDAC6 (0.44) | HDAC6HDAC8HDAC2HDAC1PAX8 | |
| Trifluoroacetic Acid SCHEMBL5423556 | 0.90 | PAX8 (0.45) | HDAC6HDAC8HDAC2MEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL5417447 | 0.89 | BCHE (0.43) | HDAC6HDAC8HDAC2MEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL5427703 | 0.88 | GPR6 (0.43) | HDAC6HDAC8HDAC2HTR2ATP53 | |
| Trifluoroacetic Acid SCHEMBL5414004 | 0.88 | HDAC2 (0.41) | HDAC6HDAC8HDAC2MCHR1PAX8 | |
| Trifluoroacetic Acid SCHEMBL5415319 | 0.88 | ALDH1A2 (0.46) | MEN1KMT2AMCHR1KCNH2DRD4 | |
| Trifluoroacetic Acid SCHEMBL5419379 | 0.88 | GPR6 (0.44) | HDAC6HDAC8HDAC2HTR2ATP53 | |
| Trifluoroacetic Acid SCHEMBL5411590 | 0.87 | ALDH1A1 (0.45) | HDAC6HDAC8HDAC2MEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL5422830 | 0.85 | LMNA (0.41) | HDAC6HDAC8HDAC2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070197603-A1 | Substituted indole ligands for the orl-1 receptor | GLAXOSMITHKLINE S.P.A. (IT) | 2007-08-23 | — | — | US | claimed |
| EP-1648881-A1 | SUBSTITUTED INDOLE LIGANDS FOR THE ORL-1 RECEPTOR | GlaxoSmithKline S.p.A. (IT) | 2006-04-26 | — | — | EP | claimed |
| WO-2005005411-A1 | SUBSTITUTED INDOLE LIGANDS FOR THE ORL-1 RECEPTOR | GLAXOSMITHKLINE S.P.A. (IT) | 2005-01-20 | — | — | WO | claimed |
| US-20070197603-A1 | Substituted indole ligands for the orl-1 receptor | GLAXOSMITHKLINE S.P.A. (IT) | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197603-A1 | Substituted indole ligands for the orl-1 receptor | OGFRL1, OPRL1, ORMDL3 | HDAC6 3419/4885HDAC8 3562/4885HDAC2 2261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.