Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.33 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.33 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5724602 | 1.00 | POLB (0.42) | POLBL3MBTL1HSD11B1P2RX7HPGD | |
| SCHEMBL5415108 | 1.00 | POLB (0.42) | POLBL3MBTL1HSD11B1P2RX7HPGD | |
| SCHEMBL3759447 | 0.87 | POLB (0.55) | POLBL3MBTL1HSD11B1P2RX7HPGD | |
| SCHEMBL3759450 | 0.87 | POLB (0.55) | POLBL3MBTL1HSD11B1P2RX7HPGD | |
| SCHEMBL31244410 | 0.81 | — | — | |
| SCHEMBL23061770 | 0.79 | SLC1A2 (0.42) | POLBL3MBTL1HSD11B1HPGD | |
| SCHEMBL5420877 | 0.79 | SLC1A2 (0.42) | POLBL3MBTL1HSD11B1HPGD | |
| SCHEMBL3466009 | 0.79 | SLC1A2 (0.42) | POLBL3MBTL1HSD11B1HPGD | |
| SCHEMBL16728466 | 0.79 | SLC1A2 (0.42) | POLBL3MBTL1HSD11B1HPGD | |
| SCHEMBL5417560 | 0.79 | SLC1A2 (0.42) | POLBL3MBTL1HSD11B1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070135445-A1 | Bicyclic Indolyl Derivatives and Methods for Their Use as Serotonergic Agents | WYETH (US) | 2007-06-14 | — | — | US | disclosed |
| US-7179813-B2 | Bicyclic indolyl derivatives and methods for their use as serotonergic agents | WYETH (US) | 2007-02-20 | — | — | US | disclosed |
| US-20050124630-A1 | Bicyclic indolyl derivatives and methods for their use as serotonergic agents | WYETH (US) | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135445-A1 | Bicyclic Indolyl Derivatives and Methods for Their Use as Serotonergic Agents | HTR4, HTR3A, TPH1 | POLB 485/4885L3MBTL1 3859/4885HSD11B1 1467/4885 |
| US-20050124630-A1 | Bicyclic indolyl derivatives and methods for their use as serotonergic agents | HTR4, HTR3A, TPH1 | POLB 485/4885L3MBTL1 3859/4885HSD11B1 1467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.