Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 2/20 | 0.59 |
| ▸ | GABRD | O14764 | 2/20 | 0.59 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.59 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.59 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.59 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.59 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.59 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.59 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.59 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.59 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.59 |
| ▸ | GABRE | P78334 | 2/20 | 0.59 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.59 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.59 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.59 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.53 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL542250 | 1.00 | GABRP (0.59) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Succinic Acid SCHEMBL542280 | 1.00 | GABRP (0.59) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Adipic Acid SCHEMBL15657487 | 0.89 | LMNA (0.58) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Adipic Acid SCHEMBL15657486 | 0.89 | LMNA (0.58) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Glutarate SCHEMBL2868168 | 0.89 | SLC22A6 (0.58) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Glutarate SCHEMBL27941460 | 0.89 | SLC22A6 (0.58) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Alpha-Ketoglutaric Acid SCHEMBL1470332 | 0.88 | EGLN1 (0.64) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Alpha-Ketoglutaric Acid SCHEMBL4364215 | 0.88 | EGLN1 (0.64) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Alpha-Ketoglutaric Acid SCHEMBL1064946 | 0.88 | EGLN1 (0.64) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Succinic Acid SCHEMBL7086022 | 0.88 | GABRP (0.65) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113005164-A | Method for improving expression level of acyl coenzyme A and application of method in fermentation production process of spiramycin | 华东理工大学 | 2021-06-22 | — | — | CN | disclosed |
| US-20160304917-A1 | Modified Microorganism for Improved Production of Alanine | BASF SE (DE) | 2016-10-20 | — | — | US | disclosed |
| EP-3039121-A1 | MODIFIED MICROORGANISM FOR IMPROVED PRODUCTION OF ALANINE | BASF SE (DE) | 2016-07-06 | — | — | EP | disclosed |
| CN-105593361-A | Modified microorganism for improved production of alanine | BASF SE | 2016-05-18 | — | — | CN | disclosed |
| WO-2015028915-A1 | MODIFIED MICROORGANISM FOR IMPROVED PRODUCTION OF ALANINE | BASF SE (DE) | 2015-03-05 | — | — | WO | disclosed |
| CN-102573845-A | Novel dicarboxylic acid linked amino acid and peptide prodrugs of opioids and uses thereof | SHIRE LLC | 2012-07-11 | — | — | CN | disclosed |
| EP-2413937-A1 | NOVEL DICARBOXYLIC ACID LINKED AMINO ACID AND PEPTIDE PRODRUGS OF OPIOIDS AND USES THEREOF | Shire LLC (US) | 2012-02-08 | — | — | EP | disclosed |
| US-20100286186-A1 | NOVEL DICARBOXYLIC ACID LINKED AMINO ACID AND PEPTIDE PRODRUGS OF OPIOIDS AND USES THEREOF | SHIRE LLC (US) | 2010-11-11 | — | — | US | disclosed |
| WO-2010112942-A1 | NOVEL DICARBOXYLIC ACID LINKED AMINO ACID AND PEPTIDE PRODRUGS OF OPIOIDS AND USES THEREOF | SHIRE LLC (US) | 2010-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286186-A1 | NOVEL DICARBOXYLIC ACID LINKED AMINO ACID AND PEPTIDE PRODRUGS OF OPIOIDS AND USES THEREOF | VIP, OPRL1, OPRK1 | GABRP 28/4885GABRD 53/4885GABRA1 159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.