Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12233267 | 0.84 | ALDH1A1 (0.44) | L3MBTL1ALDH1A1HSD17B10MAPK1HPGD | |
| SCHEMBL18112642 | 0.76 | ALDH1A1 (0.48) | GAAL3MBTL1ALDH1A1NPSR1HSD17B10 | |
| SCHEMBL6876786 | 0.74 | GAA (0.58) | GAAL3MBTL1ALDH1A1NPSR1HSD17B10 | |
| SCHEMBL25211939 | 0.73 | GAA (0.57) | GAAL3MBTL1ALDH1A1NPSR1HSD17B10 | |
| SCHEMBL10309075 | 0.73 | GAA (0.57) | GAAL3MBTL1ALDH1A1NPSR1HSD17B10 | |
| SCHEMBL15840964 | 0.73 | GAA (0.57) | GAAL3MBTL1ALDH1A1NPSR1HSD17B10 | |
| SCHEMBL6187607 | 0.73 | MAPK1 (0.64) | GAAL3MBTL1ALDH1A1NPSR1HSD17B10 | |
| SCHEMBL8658204 | 0.71 | MAPK1 (0.62) | GAAL3MBTL1ALDH1A1NPSR1HSD17B10 | |
| SCHEMBL15330130 | 0.70 | GAA (0.54) | GAAL3MBTL1ALDH1A1NPSR1HSD17B10 | |
| SCHEMBL21602433 | 0.70 | L3MBTL1 (0.71) | GAAL3MBTL1ALDH1A1NPSR1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0956855-B1 | Immunosuppressive effects of 8 substituted xanthine derivatives | LEUVEN K U RES & DEV (BE) | 2003-03-12 | — | — | EP | claimed |
| EP-0956855-A1 | Immunosuppressive effects of 8-substituted xanthine derivatives | K.U. Leuven Research & Development (BE) | 1999-11-17 | — | — | EP | claimed |
| US-7253176-B1 | Immunosuppressive effects of 8-substituted xanthine derivatives | K.U. LEUVEN RESEARCH & DEVELOPMENT (BE) | 2007-08-07 | — | — | US | disclosed |
| EP-0956855-B1 | Immunosuppressive effects of 8 substituted xanthine derivatives | LEUVEN K U RES & DEV (BE) | 2003-03-12 | — | — | EP | disclosed |