Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | THPO | P40225 | 1/20 | 0.31 |
| ▸ | PPM1B | O75688 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.31 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.31 |
| ▸ | PPP5C | P53041 | 1/20 | 0.31 |
| ▸ | PPP2CA | P67775 | 1/20 | 0.31 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23008043 | 0.68 | ABCB1 (0.41) | MAPK1KDM4EMEN1MAPTTSHR | |
| SCHEMBL14867116 | 0.68 | MAPT (0.31) | NPC1RAB9AMAPTKMT2A | |
| SCHEMBL8630324 | 0.68 | ABCB1 (0.41) | MAPK1KDM4EMEN1MAPTTSHR | |
| SCHEMBL24475291 | 0.68 | MAPT (0.31) | NPC1RAB9AMAPTKMT2A | |
| SCHEMBL15856565 | 0.68 | MAPT (0.34) | NPC1RAB9AMAPTKMT2A | |
| SCHEMBL23566047 | 0.68 | MAPT (0.31) | NPC1RAB9AMAPTKMT2A | |
| SCHEMBL8630325 | 0.68 | ABCB1 (0.41) | MAPK1KDM4EMEN1MAPTTSHR | |
| SCHEMBL24791473 | 0.67 | — | — | |
| SCHEMBL21567768 | 0.67 | — | — | |
| SCHEMBL5529323 | 0.67 | NPC1 (0.31) | NPC1RAB9AMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070135445-A1 | Bicyclic Indolyl Derivatives and Methods for Their Use as Serotonergic Agents | WYETH (US) | 2007-06-14 | — | — | US | disclosed |
| US-7179813-B2 | Bicyclic indolyl derivatives and methods for their use as serotonergic agents | WYETH (US) | 2007-02-20 | — | — | US | disclosed |
| EP-1644355-A1 | BICYCLIC INDOLYL DERIVATIVES AND METHODS OF THEIR USE AS SEROTONERGIC AGENTS | Wyeth (US) | 2006-04-12 | — | — | EP | disclosed |
| US-20050124630-A1 | Bicyclic indolyl derivatives and methods for their use as serotonergic agents | WYETH (US) | 2005-06-09 | — | — | US | disclosed |
| WO-2004111035-A1 | BICYCLIC INDOLYL DERIVATIVES AND METHODS OF THEIR USE AS SEROTONERGIC AGENTS | WYETH (US) | 2004-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135445-A1 | Bicyclic Indolyl Derivatives and Methods for Their Use as Serotonergic Agents | HTR4, HTR3A, TPH1 | CYP19A1 1631/4885TP53 3433/4885CYP3A4 685/4885 |
| US-20050124630-A1 | Bicyclic indolyl derivatives and methods for their use as serotonergic agents | HTR4, HTR3A, TPH1 | CYP19A1 1631/4885TP53 3433/4885CYP3A4 685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.