Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 7/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.49 |
| ▸ | QPCT | Q16769 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5424440 | 0.83 | MMP13 (0.52) | MMP13ROCK1ROCK2HDAC3HDAC4 | |
| SCHEMBL2491607 | 0.82 | MMP13 (0.64) | MMP13ROCK1ROCK2HDAC3HDAC4 | |
| SCHEMBL2315834 | 0.82 | MMP13 (0.64) | MMP13ROCK1ROCK2HDAC3HDAC4 | |
| SCHEMBL19338476 | 0.79 | MMP13 (0.65) | MMP13ROCK1ROCK2HDAC3HDAC4 | |
| SCHEMBL5124722 | 0.78 | HDAC6 (0.62) | MMP13ROCK1ROCK2HDAC3HDAC4 | |
| SCHEMBL3085533 | 0.78 | MMP13 (0.55) | MMP13ROCK1ROCK2HDAC3HDAC4 | |
| SCHEMBL29147374 | 0.78 | MMP13 (0.64) | MMP13ROCK1ROCK2HDAC3HDAC4 | |
| SCHEMBL31549960 | 0.75 | KDM4E (0.51) | MMP13ROCK1ROCK2HDAC3HDAC4 | |
| SCHEMBL5432980 | 0.75 | MMP13 (0.50) | MMP13HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2317224 | 0.74 | MMP13 (0.59) | MMP13SLC22A8KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070270589-A1 | Quinazoline Derivative and Process for Producing the Same | MITSUBISHI PHARMA CORPORATION (JP) | 2007-11-22 | — | — | US | claimed |
| EP-1690856-A1 | QUINAZOLINE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME | Mitsubishi Pharma Corporation (JP) | 2006-08-16 | — | — | EP | claimed |
| US-20070270589-A1 | Quinazoline Derivative and Process for Producing the Same | MITSUBISHI PHARMA CORPORATION (JP) | 2007-11-22 | — | — | US | disclosed |
| EP-1690856-A1 | QUINAZOLINE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME | Mitsubishi Pharma Corporation (JP) | 2006-08-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270589-A1 | Quinazoline Derivative and Process for Producing the Same | TP53, NQO2, AQP1 | MMP13 3452/4885ROCK1 1886/4885ROCK2 2626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.