Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31478884 | 0.77 | NPSR1 (0.44) | NPC1ABCB1KMT2AAURKARPS6KB1 | |
| SCHEMBL11494793 | 0.76 | OPRK1 (0.46) | KMT2A | |
| SCHEMBL11193687 | 0.76 | ABCB1 (0.56) | ABCB1KMT2ADRD3 | |
| SCHEMBL27870313 | 0.74 | BCAT2 (0.44) | KMT2ACHRM2 | |
| SCHEMBL29493488 | 0.74 | BCAT2 (0.53) | NPC1KMT2A | |
| SCHEMBL542488 | 0.71 | ALDH1A1 (0.50) | NPC1KMT2APOLB | |
| Acetic Acid SCHEMBL8910187 | 0.70 | BCAT2 (0.53) | NPC1KMT2A | |
| SCHEMBL7101608 | 0.69 | NPC1 (0.76) | NPC1KMT2ANPSR1POLB | |
| SCHEMBL17729936 | 0.68 | BCAT2 (0.59) | KMT2ANPSR1HRH3 | |
| SCHEMBL10856438 | 0.68 | CHRM2 (0.53) | ABCB1KMT2ACHRM2ADRA2BDRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414543-A1 | GENETIC MARKERS FOR RISK MANAGEMENT OF ATRIAL FIBRILLATION AND STROKE | Decode Genetics EHF (IS) | 2012-02-08 | — | — | EP | disclosed |