Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.39 |
| ▸ | ADA | P00813 | 1/20 | 0.38 |
| ▸ | NT5E | P21589 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5415616 | 0.88 | ADORA2A (0.44) | ALDH1A1ADORA2AKMT2ALMNAADA | |
| SCHEMBL5419236 | 0.88 | ADORA2A (0.44) | ALDH1A1ADORA2AKMT2ALMNAADA | |
| SCHEMBL19352192 | 0.84 | ADORA2A (0.48) | ADORA2AKMT2ALMNAADANT5E | |
| SCHEMBL19352194 | 0.84 | ADORA2A (0.48) | ADORA2AKMT2ALMNAADANT5E | |
| SCHEMBL5424936 | 0.83 | ALDH1A1 (0.46) | ALDH1A1ADORA2AGAAKMT2ALMNA | |
| SCHEMBL19352193 | 0.80 | ADORA3 (0.50) | ADORA2ASTING1NT5EADORA3PDE3A | |
| SCHEMBL14594720 | 0.80 | ADORA3 (0.50) | ADORA2ASTING1NT5EADORA3PDE3A | |
| Thioguanosine SCHEMBL29430188 | 0.78 | ADORA2A (0.54) | ALDH1A1ADORA2AKMT2ALMNANT5E | |
| Ateganosine SCHEMBL29420101 | 0.77 | PNP (0.55) | ALDH1A1LMNAHIF1ASMN1; SMN2PDE4D | |
| Ateganosine SCHEMBL536937 | 0.77 | PNP (0.55) | ALDH1A1LMNAHIF1ASMN1; SMN2PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070004669-A1 | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase | CARROLL STEVEN S | 2007-01-04 | — | — | US | claimed |
| EP-1551421-A2 | NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE | MERCK & CO. INC. (US) | 2005-07-13 | — | — | EP | claimed |
| WO-2004000858-A2 | NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE | MERCK & CO., INC. (US) | 2003-12-31 | — | — | WO | claimed |
| US-20070004669-A1 | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase | CARROLL STEVEN S | 2007-01-04 | — | — | US | disclosed |
| EP-1551421-A2 | NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE | MERCK & CO. INC. (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004000858-A2 | NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE | MERCK & CO., INC. (US) | 2003-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004669-A1 | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase | NSUN2, NSUN3, POLRMT | ALDH1A1 1371/4885ADORA2A 416/4885GAA 761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.